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NCT07595263PHASE1RecruitingAccepts Healthy Volunteers

A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)

Merck Sharp & Dohme LLC

Start Date

8/17/2026

Completion Date

1/15/2027

Summary

This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria The main Inclusion Criteria include but are not limited to: * Is in good health * Has a body mass index (BMI) between \>18 and ≤40 kg/m\^2 * Is reliably participating in a methadone maintenance program for at least 2 months prior to Day 1 and is on a documented stable dose of methadone for at least 14 days prior to Day 1 Exclusion Criteria The main Exclusion Criteria include but are not limited to: * Has a history of cancer (malignancy) * Has a history of significant multiple and/or severe allergies, or has had an anaphylactic reaction or significant intolerability to prescription or nonprescription drugs or food * Has tested positive human immunodeficiency virus (HIV) or for a sexually transmitted infection at screening * Is under the age of legal consent

Interventions

DRUG

Ulonivirine

DRUG

Methadone

Interested in This Trial?

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Conditions

Healthy

Locations

Pinnacle Research Group ( Site 0002)

Anniston, Alabama 36207

United States