NCT07595263PHASE1RecruitingAccepts Healthy Volunteers
A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)
Merck Sharp & Dohme LLC
Start Date
8/17/2026
Completion Date
1/15/2027
Summary
This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.
Eligibility Criteria
Age Range: 18 years to 65 years
Inclusion Criteria
The main Inclusion Criteria include but are not limited to:
* Is in good health
* Has a body mass index (BMI) between \>18 and ≤40 kg/m\^2
* Is reliably participating in a methadone maintenance program for at least 2 months prior to Day 1 and is on a documented stable dose of methadone for at least 14 days prior to Day 1
Exclusion Criteria
The main Exclusion Criteria include but are not limited to:
* Has a history of cancer (malignancy)
* Has a history of significant multiple and/or severe allergies, or has had an anaphylactic reaction or significant intolerability to prescription or nonprescription drugs or food
* Has tested positive human immunodeficiency virus (HIV) or for a sexually transmitted infection at screening
* Is under the age of legal consent
Interventions
DRUG
Ulonivirine
DRUG
Methadone
Conditions
Healthy
Locations
Pinnacle Research Group ( Site 0002)
Anniston, Alabama 36207
United States