NCT07606573NARecruitingAccepts Healthy Volunteers
The SEAS Study: Sensory Engagement and Activation During Noninvasive Stimulation
University of Minnesota
Start Date
6/8/2026
Completion Date
2/1/2028
Summary
Early feasibility study to establish quantitative physiological markers correlated with noninvasive stimulation.
Detailed Description
This pilot early feasibility study in healthy participants is intended to establish quantitative physiological markers of cortical and autonomic modulation evoked by noninvasive electrical and/or ultrasound stimulation of the nervous system.
Eligibility Criteria
Age Range: 18 years to 65 years
Inclusion Criteria:
* Able to provide written informed consent in English.
* Willing and able to complete study procedures (e.g., \~1-hour sessions with non-invasive recordings, \~3-hour visit).
Exclusion Criteria:
* History of neurological disorders (e.g., epilepsy, migraines) or psychiatric conditions requiring medication.
* Active implanted medical devices (e.g., pacemakers, cochlear implants) or metal in the neck/forearm that could interfere with stimulation or recordings.
* Skin conditions or open wounds at stimulation sites (cervical neck, forearm).
* Women who are pregnant or breastfeeding.
* Current use of medications affecting autonomic or cortical function (e.g., beta-blockers, sedatives).
* Inability to sit still for recordings or understand instructions (e.g., due to severe vision/hearing impairment).
Interventions
DEVICE
External electrical stimulation
DEVICE
Ultrasound stimulation
Conditions
Healthy Adult Participants
Locations
M Health Clinical Research Unit
Minneapolis, Minnesota 55455
United States
M Health Clinics and Surgery Center and satellite Neurology Clinic locations
Minneapolis, Minnesota 55455
United States
Translational Neurotechnology (TNT) Lab
Minneapolis, Minnesota 55455
United States