BL-M14D1 Plus Atezolizumab vs Standard of Care in First-Line Extensive-Stage Small Cell Lung Cancer (BrenDeLL-Lung01)
Start Date
8/4/2026
Completion Date
6/1/2031
Summary
The objective of the study is to evaluate the efficacy and safety of BL-M14D1 in combination with Atezolizumab compared to Standard-of-Care Therapy in adult participants with previously untreated extensive-stage small cell lung cancer (ES-SCLC).
Detailed Description
This study is a Global Phase 3, open-label, multicenter study designed to evaluate the efficacy and safety of BL-M14D1 in combination with atezolizumab compared with standard-of-care therapy in adult participants with previously untreated extensive-stage small cell lung cancer (ES-SCLC). Standard-of-care therapy consists of carboplatin plus etoposide chemotherapy and atezolizumab, followed by maintenance treatment with atezolizumab with or without lurbinectedin.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BL-M14D1 and Atezolizumab
Carboplatin+ Etoposide + Atezolizumab followed by Atezolizumab and Lurbinectedin
Conditions
Locations
Highlands Oncology Group
Springdale, Arkansas 72762
United States
Los Alamitos Hematology/Oncology Medical Group
Glendale, California 91203
United States
MemorialCare Todd Cancer Institute
Long Beach, California 90806
United States
Valkyrie Clinical Trials
Los Angeles, California 90067
United States
Total Health and Research Center
Miami, Florida 33176
United States
Astera Cancer Care
East Brunswick, New Jersey 08816
United States
Virginia Cancer Specialists
Fairfax, Virginia 22031
United States
Canberra Hospital
Garran, Australian Capital Territory 2605
Australia
Tasman Oncology
Southport, Queensland 4215
Australia
Flinders Medical Centre
Bedford Park, South Australia 5042
Australia
MHAT Dr. Tota Venkova
Gabrovo, 5300
Bulgaria
MHAT Heart and Brain
Pleven, 5800
Bulgaria
Medical Centre FutureMeds
Plovdiv, 1431
Bulgaria
MHAT Pulmed
Plovdiv, 4002
Bulgaria
UMHAT Sveti Ivan Rilski
Sofia, 1431
Bulgaria
MHAT Serdikamed
Sofia, 1632
Bulgaria
Arthur Child Cancer Centre
Calgary, Alberta T2N 5G2
Canada
University of Sherbrooke
Greenfield Park, Quebec J4V 2H1
Canada
Nemocnice České Budějovice, a.s.
České Budějovice, 370 01
Czechia
Nemocnice Agel Vítkovice
Ostrava, 703 00
Czechia
Fakultní nemocnice Ostrava (FN Ostrava)
Ostrava-Poruba, 708 52
Czechia
Organization Centre Hospitalier Intercommunal de Creteil (CHIC) - Centre de Recherche Clinique (CRC) (Clinical Research Center)
Créteil, 94010
France
CLB - Centre Léon Bérard
Lyon, 69008
France
IPC - lnstitut Paoli-Calmettes
Marseille, 13273
France
Universite Pierre et Marie Curie (UPMC) - Center de Recherche des Cordeliers (CRC)
Paris, 75005
France
ICO - L'Institut de Cancérologie de L'Ouest
Saint-Herblain, 44805
France
LTD High Technology Hospital Medcenter
Tbilisi, 0114
Georgia
Ltd New Hospitals
Tbilisi, 0114
Georgia
Pineo Medical Ecosystem LtD
Tbilisi, 0114
Georgia
LLC Todua Clinic
Tbilisi, 0119
Georgia
The First Medical Clinic LLC
Tbilisi, 0180
Georgia
Caucasus Medical Centre
Tbilisi, 0186
Georgia
Lungenklinik/Lungenkrebszentrum Köln-Merheim
Cologne, 51109
Germany
KEM | Evangelische Kliniken Essen Mitte gGmbH
Essen, 45136
Germany
Krankenhaus Martha-Maria Halle-Dölau
Halle, 06120
Germany
Henry Dunant Hospital Center
Athens, 11526
Greece
Theageneio Anticancer Hospital
Thessaloniki, 54639
Greece
St Luke's Hospital
Thessaloniki, 55236
Greece
European Interbalkan Medical Center
Thessaloniki, 57001
Greece
Semmelweis University Department of Pulmonology
Budapest, 1083
Hungary
Mátrai Gyógyintézet
Gyöngyös, 7151
Hungary
Bács-Kiskun Vármegyei Oktatókórház, Oncoradiology Center
Kecskemét, 6000
Hungary
Református Pulmonológiai Intézet
Törökbálint, 2045
Hungary
Centro di Riferimento Oncologico
Aviano, 33081
Italy
Policlinico Paolo Giaccone University Hospital
Palermo, 90127
Italy
Regina Elena Institute for Cancer Research
Roma, 00144
Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, 00168
Italy
AOUS Le Scotte, UOC Immunoterapia Oncologica
Siena, 53100
Italy
Uniwersytecki Szpital Kliniczny w Bialymstoku, II Klinika Chorob Pluc, Raka Pluca i Chorob Wewnetrznych
Bialystok, 15-540
Poland
Szpitale Pomorskie Spolka z ograniczona odpowiedzialnoscia, Oddzial Onkologii i Radioterapii - Dzial Onkologii Klinicznej
Gdynia, 81-519
Poland
Oddzial Onkologii Klinicznej
Katowice, 40-514
Poland
Instytut "Centrum Zdrowia Matki Polki", Klinika Onkologii
Lodz, 93-338
Poland
Szpital Specjalistyczny w Prabutach Spolka z ograniczona odpowiedzialnoscia, Oddzial pulmonologii
Prabuty, 82-550
Poland
University Clinical Centre of Serbia, Clinic for pulmonology
Belgrade, 11000
Serbia
University Hospital Medical Center Bezanijska Kosa
Belgrade, 11000
Serbia
University Clinical Center Kragujevac
Kragujevac, 34000
Serbia
Institute for pulmonary diseases of Vojvodina
Novi Sad, 21208
Serbia
Complejo Hospitalario Universitario A Coruna (CHUAC) - Hospital Teresa Herrera
A Coruña, 15006
Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041
Spain
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, 35016
Spain
Hospital Clinico San Carlos
Madrid, 28040
Spain
Centro de Investigación Oncológica Clara Campal
Madrid, 28050
Spain