NCT07641361NARecruiting

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

State University of New York at Buffalo

Start Date

6/15/2026

Completion Date

2/1/2027

Summary

This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side effects, and drug discontinuation associated with GLP - 1 RA therapy. The investigators are piloting to assess feasibility and preliminary efficacy of the intervention through examining participant retention, participant feedback, researcher and participant adherence to protocols, impact on hydration biomarkers, and participant reported GLP - 1 RA side effects.

Eligibility Criteria

Age Range: 18 years to 60 years

Inclusion Criteria: * Adults aged 18-60 * Recently prescribed a GLP-1RA (within one week of prescription) * Fluent in English * Willing to complete the study protocol Exclusion Criteria: * Children and adults \> 60 years of age * Those not taking a GLP-1RA * Those who have been on a GLP-1RA longer than one week * Not fluent in English * Those who are pregnant or planning on becoming pregnant during the duration of the study * Unwilling to comply with study protocol * People with cardiac implants

Interventions

BEHAVIORAL

Hydration Plus

BEHAVIORAL

Control

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Conditions

Obesity & OverweightType 2 DiabetesType 2 Diabetes (Adult Onset)Obesity Type 2 Diabetes MellitusDehydration

Locations

State University of New York at Buffalo, South Campus

Buffalo, New York 14214

United States