NCT07674680EARLY_PHASE1RecruitingAccepts Healthy Volunteers

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

University of Missouri-Columbia

Start Date

7/31/2026

Completion Date

5/1/2029

Summary

To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

Eligibility Criteria

Age Range: 18 years to 70 years

Inclusion Criteria: * Healthy women, * Assigned female at birth, * 18-70 years of age, * Body mass index \<18 or ≥30 kg/m2, Exclusion Criteria: * Assigned male at birth, * Pregnancy, * Breastfeeding, * History of hormone replacement therapy, chemical menopause, or oophor-ectomy * Polycystic ovarian syndrome or Primary ovarian insufficiency, * Current smoking/Nicotine use, * Blood pressure ≥140/90 mmHg, * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy, * Nerve/neurologic disease, * Cardiovascular, hepatic, renal, respiratory disease, * Hypersensitivity to nitroglycerin, * Diabetes, * Communication barriers,

Interventions

DRUG

Placebo

DRUG

Gemtesa

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Conditions

WomenAgingMenopause

Locations

University of Missouri

Columbia, Missouri 65211

United States