NCT07689162PHASE2Recruiting

Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia

Washington University School of Medicine

Start Date

8/1/2026

Completion Date

7/1/2027

Summary

The purpose of this study is to find out which pain medication is more effective in reducing pain after nose surgery (rhinoplasty). The investigators are looking to find the best treatment to reduce discomfort and improve the healing process for patients having nose surgery.

Detailed Description

The investigators are comparing two types of pain relief medications: Liposomal Bupivacaine and Standard Bupivacaine. Participants who are undergoing rhinoplasty will be randomly assigned to receive either Liposomal Bupivacaine or Standard Bupivacaine during their surgery. Both medications are given as nerve blocks, which means they are injected near nerves to block pain signals. After the surgery, participants will be asked to rate their pain levels over several days. The investigators will also monitor any side effects and how quickly participants recover from the surgery.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult patients (≥18 years) undergoing open rhinoplasty of any indication or complexity (e.g., primary, revision, functional, or cosmetic), including autologous grafting of any type (e.g., septal or costal cartilage) or cadaveric grafting. Exclusion Criteria: * Chronic pain condition requiring ongoing or scheduled analgesic therapy, or any diagnosis associated with chronic pain (e.g., fibromyalgia, chronic headache/migraine, neuropathic pain, complex regional pain syndrome), long-term opioid use (≥3 months, any agent), allergy or contraindication to local anesthetics, acetaminophen, ibuprofen / NSAIDs, tramadol, ketamine, Medrol (methylprednisolone) dose pack * Concurrent non-nasal surgery planned

Interventions

DRUG

Standard Bupivacaine

DRUG

Liposomal Bupivacaine

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Conditions

Pain, Postoperative

Locations

Washington University

St Louis, Missouri 63110

United States