Skip to main content
Back to Trials
NCT07690852RecruitingAccepts Healthy Volunteers

Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care

City of Hope Medical Center

Start Date

12/28/2026

Completion Date

1/1/2028

Summary

This study evaluates patient and provider attitudes about environmental exposure risk assessments into clinical care for female patients at average or high risk for breast cancer and/or diagnosed with early onset breast cancer.

Detailed Description

PRIMARY OBJECTIVES: I. To assess patient interest and emotional responses toward EERA and return of results. II. To assess provider attitudes toward EERA integration into clinical workflows. OUTLINE: This is an observational study. Participants are assigned to 1 of 3 aims. AIM I: Average and high risk breast cancer participants and early onset breast cancer patients complete a survey over 15-25 minutes and may attend an interview over 30-45 minutes. Participants' and patients' medical records are reviewed. AIM II: COH providers complete a survey over 15-25 minutes and may attend an interview over 30-45 minutes. AIM III: Average and high risk breast cancer participants complete a baseline survey over 15-25 minutes and wear Fresh Air Clip wristbands for 1 week. Participants then complete a follow up survey over 15-25 minutes and may attend an interview over 30-45 minutes. Participants' medical records are reviewed.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * AIM 1 INCLUSION CRITERIA: * ONE of the following: * Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no Pathogenic/Likely Pathogenic \[P/LP\] in breast cancer related genes) OR high risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model or gene mutation carrier, P/LP carrier in breast cancer related genes including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53) OR early onset breast cancer (defined by a breast cancer diagnosis in a patient younger than 50 years of age) * Age: ≥ 18 years * Speak English or Spanish * Sex: female * Willingness to: * Participate in study activities * Permit medical record/ clinical laboratory result review * AIM 2 INCLUSION CRITERIA * Practice at COH (i.e., genetic counselors, geneticists, oncologists, nurse practitioners) * Willingness to: * Participate in study activities * AIM 3 INCLUSION CRITERIA: * Provide written consent * ONE of the following: * Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no P/LP in breast cancer related genes) OR High risk: empirical risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model and no P/LP in breast cancer related genes) OR High Risk: gene carrier (defined by P/LP carrier in breast cancer related genes, including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53) * Age: ≥ 18 years * Speak English or Spanish * Sex: female * Willingness to: * Wear the wristband for 1 week * Participate in study activities * Permit medical record/ clinical laboratory result review

Interventions

OTHER

Non-Interventional Study

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Breast Carcinoma

Locations

City of Hope Medical Center

Duarte, California 91010

United States