NCT07702539NARecruitingAccepts Healthy Volunteers

NASA Exercise Prebreathe Study

Duke University

Start Date

8/13/2026

Completion Date

2/27/2027

Summary

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Eligibility Criteria

Age Range: 30 years to 60 years

Inclusion Criteria: * Non-smoking volunteers aged 30-60 years * Able to meet VO2 peak requirements (\>35 ml/kg/min males, \>30 ml/kg/min females) Exclusion Criteria: * Pregnancy * Lung disease, heart disease, hypertension, or diabetes * Musculoskeletal pain conditions * Requirement for regular medications such as analgesics

Interventions

PROCEDURE

Oxygen Prebreathe and Hypobaric Exposure

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Conditions

Decompression Sickness

Locations

Duke University Medical Center

Durham, North Carolina 27710

United States