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NCT07713940NARecruiting

Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous

University of California, San Diego

Start Date

7/1/2026

Completion Date

7/1/2029

Summary

To study the effect of anti-inflammatory diet on clinical and biological outcomes in lupus

Detailed Description

The investigators aim to evaluate how inflammation changes in individuals with lupus and to identify molecules and gut bacteria that may help predict disease flares. Blood and stool samples will be analyzed in the laboratory and compared with samples collected from the same participants following dietary changes. This is an exploratory study designed to generate preliminary data on the short-term effects of dietary changes and treatment on blood biomarkers and the gut microbiome. The findings may provide insights into the mechanisms underlying lupus and could ultimately contribute to the development of new therapeutic approaches.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * patients who meet the 2019 EULAR/ACR Classification Criteria for SLE * patients who are on Cellcept or Myfortic for at least 3 months prior to screening * patients with a score of ≥55 on the Patient Reported Outcomes Measurement Information System (PROMIS) Pain interference scale. Exclusion Criteria: * pregnant or lactating patients, * patients with food allergy * patients on antibiotics within 4 weeks of the screening * patients that change the SLE therapy during the length of the study (12 weeks).

Interventions

DIETARY_SUPPLEMENT

anti-inflammatory diet

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Conditions

Systemic Lupus Erthematosus (SLE)

Locations

Altman Clinical Translational Research Insitute (UC San Diego)

La Jolla, California 92097

United States