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NCT07715006NARecruiting

Dorsal Root Electrical Stimulation in Children With Cerebral Palsy

Martin Piazza

Start Date

7/16/2026

Completion Date

12/1/2029

Summary

The goal of this clinical trial is to evaluate whether dorsal root electrical stimulation could reduce spasticity in children with cerebral palsy (CP).

Detailed Description

The investigators will recruit participants with CP requiring selective dorsal rhizotomy (SDR) surgery. During SDR, spastic dorsal roots are routinely identified by electrically stimulating each root at low frequency (1 Hz) and measuring the resulting muscle response via electromyography - a procedure called "clinical test stimulation." Dorsal roots that produce an abnormally large and widespread compound muscle action potential (CMAP) are classified as spastic. In this study, the investigators will superimpose higher-frequency dorsal root stimulation (40-5000 Hz) on top of this standard clinical test stimulation and assess whether it suppresses the abnormal large CMAP.

Eligibility Criteria

Age Range: 3 years to 14 years

Inclusion Criteria: * Children ages 3 to 14 * Diagnosis of Cerebral Palsy * Require an SDR as determined by the multidisciplinary movement disorders team * Confirmation that subjects' terms of insurance coverage for their standard of care procedure will not be altered by study enrollment. Exclusion Criteria: * No exclusion criteria

Interventions

DEVICE

Constant Current Stimulator

DEVICE

Cadwell Guardian System

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Conditions

Cerebral Palsy (CP)Cerebral PalsySpasticitySpasticity Due to Cerebral Palsy

Locations

UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania 15224

United States