NCT07717502NARecruiting
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
Ochsner Health System
Start Date
8/18/2026
Completion Date
12/1/2027
Summary
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex pregnancies at term undergoing induction of labor.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Nulliparous patients with singleton pregnancies with vertex lie at term receiving prenatal care that are eligible for outpatient cervical ripening will be eligible
Exclusion Criteria:
* age less than 18,
* suspected major fetal anomalies (including suspected or proven chromosome anomalies, congenital cardiac disease expected to require neonatal intervention, and multiple anomalies suggestive of a complex syndrome),
* fetal growth restriction
* oligohydramnios
* prior full thickness
* uterine scar
* placenta previa,
* low-lying placenta,
* premature rupture of amniotic membranes,
* cervical dilation \> 2 cm
* modified Bishop score \> 4
* residence greater than 60 minutes from the hospital
Interventions
COMBINATION_PRODUCT
Sequential Cervical Ripening
COMBINATION_PRODUCT
Inpatient Combined Cervical Ripening
Conditions
Nulliparous Women Who Scheduled for Labor InductionPregnancy
Locations
Ochsner Baptist
New Orleans, Louisiana 70115
United States