Skip to main content
Back to Trials
NCT07734610PHASE1RecruitingAccepts Healthy Volunteers

A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)

Merck Sharp & Dohme LLC

Start Date

9/8/2026

Completion Date

2/1/2027

Summary

The purpose of this study is to learn what happens to nemtabrutinib in a person's body when given to participants with severe kidney disease and to healthy participants.

Eligibility Criteria

Age Range: 18 years to 80 years

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: All participants: * Has a body mass index (BMI) ≥18.0 and ≤40.0 kg/m\^2 Participants with Severe Renal impairment (RI): * The participant has stable renal function as determined by historical measurements. Healthy volunteers: * Is medically healthy with no clinically significant medical history Exclusion Criteria: The main exclusion criteria include but are not limited to the following: Renal Impairment Participants: * History of any illness, other than renal impairment, that, in the opinion of the investigator, might confound the results of the study or poses an additional risk to the participant by their participation in the study. Healthy Matched Control Participants: * History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. Participants with a remote history of uncomplicated medical events (eg, uncomplicated kidney stones, as defined as spontaneous passage and no recurrence in the last 5 years, or childhood asthma) may be enrolled in the study at the discretion of the investigator

Interventions

DRUG

Nemtabrutinib

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Severe Renal ImpairmentHealthy

Locations

Floridian Clinical Research, LLC ( Site 0001)

Miami Lakes, Florida 33016

United States