Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Start Date
7/22/2026
Completion Date
5/3/2028
Summary
This study is a Phase 1/2, randomized, observer-blind, active and placebo-controlled, multi-center study to be conducted in approximately 2400 adults 60 years of age and older. The aim of the study is to evaluate the immunogenicity and safety of an RSV+HMPV vaccine candidate for the prevention of RSV and HMPV disease among adults 60 years of age and older. While there are 3 FDA approved/licensed RSV vaccines currently available to the public, no vaccine is available for the prevention of HMPV in older adults. This study is intended to provide data in support of further clinical development of the RSV+HMPV vaccine candidate. The study will consist of 4 cohorts and 11 vaccine groups (RSV+HMPV \[6 dose levels\], placebo and 4 control groups). The duration of the study will be approximately 12 months for each participant.
Eligibility Criteria
Age Range: 60 years to No maximum
Interventions
RSV+HMPV vaccine
Control Vaccine 3
Control Vaccine 4
Control Vaccine 2
Placebo
Control Vaccine 1
Conditions
Locations
Hawthorne Health - Gadsden City Pharmacy- Site Number : 8400025
Gadsden, Alabama 35901
United States
Scottsdale Clinical Trials- Site Number : 8400011
Scottsdale, Arizona 85260
United States
Long Beach Research Institute- Site Number : 8400005
Long Beach, California 90805
United States
Alliance Clinical - San Diego- Site Number : 8400033
San Diego, California 92120
United States
Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400064
DeLand, Florida 32720
United States
Accel Research Sites - NeuroStudies- Site Number : 8400063
Decatur, Georgia 30030
United States
DM Clinical Research - Chicago- Site Number : 8400050
Melrose Park, Illinois 60160
United States
DM Clinical Research - Detroit- Site Number : 8400049
Southfield, Michigan 48076
United States
Velocity Clinical Research - Lincoln - Valley Road- Site Number : 8400016
Lincoln, Nebraska 68510
United States
Alliance Clinical - Las Vegas- Site Number : 8400034
Las Vegas, Nevada 89109
United States
Hawthorne Health - Staten Island- Site Number : 8400026
Staten Island, New York 10309
United States
DM Clinical Research - Philadelphia- Site Number : 8400046
Philadelphia, Pennsylvania 19107
United States
Coastal Carolina Research Center - North Charleston- Site Number : 8400061
North Charleston, South Carolina 29405
United States
Velocity Clinical Research - Austin- Site Number : 8400013
Austin, Texas 78759
United States
DM Clinical Research - Sugar Land- Site Number : 8400048
Sugar Land, Texas 77478
United States
DM Clinical Research - Tomball- Site Number : 8400045
Tomball, Texas 77375
United States
Charlottesville Medical Research- Site Number : 8400062
Charlottesville, Virginia 22911
United States