NCT07739992NARecruiting

Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

Milap Sandhu

Start Date

7/27/2026

Completion Date

7/1/2028

Summary

This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: * Chronic Spinal Cord Injury (\>6 months) * Motor incomplete SCI classified as AIS C or D * Volitional ankle plantarflexion strength in at least one leg Exclusion Criteria: * Uncontrolled hypertension (outside 140/90 and 90/60) * Concurrent medical illness * Traumatic brain injury * Cardiovascular complications * Pulmonary complications * Metabolic dysfunction * Continued use of anti-spasticity medications * Previously diagnosed obstructive sleep apnea

Interventions

OTHER

Sham AIH

OTHER

Acute Intermittent Hypoxia (AIH) 15

OTHER

Acute Intermittent Hypoxia (AIH) 23

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Conditions

Spinal Cord Injuries (SCI)

Locations

Shirley Ryan AbilityLab

Chicago, Illinois 60611

United States