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NCT07745920NARecruiting

Managing Depressive Symptoms in ADPKD

Mayo Clinic

Start Date

6/12/2026

Completion Date

7/12/2027

Summary

The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.

Eligibility Criteria

Age Range: 18 years to 70 years

Inclusion criteria: * Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria * Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR \>10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months) * Clinical or self-diagnosis of depression * English-language fluency Exclusion criteria: * Suicidal ideation/unstable mental illness of any kind * Lack of access/ability to use internet-based programs * eGFR \<10 ml/min/1.73m2 * Anticipated dialysis or transplant within 6 months * Prior chronic dialysis * Prior organ (liver or kidney) transplant * Lack of English language fluency * Significant cognitive impairment (Mini Mental Status Exam (MMSE))

Interventions

BEHAVIORAL

Mayo Clinic-Approved Education

BEHAVIORAL

Digital Neuropathy

BEHAVIORAL

Capacity Coaching

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Conditions

Autosomal Dominant Polycystic Kidney Disease

Locations

Mayo Clinic

Rochester, Minnesota 55905

United States