NCT07745920NARecruiting
Managing Depressive Symptoms in ADPKD
Mayo Clinic
Start Date
6/12/2026
Completion Date
7/12/2027
Summary
The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion criteria:
* Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria
* Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR \>10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months)
* Clinical or self-diagnosis of depression
* English-language fluency
Exclusion criteria:
* Suicidal ideation/unstable mental illness of any kind
* Lack of access/ability to use internet-based programs
* eGFR \<10 ml/min/1.73m2
* Anticipated dialysis or transplant within 6 months
* Prior chronic dialysis
* Prior organ (liver or kidney) transplant
* Lack of English language fluency
* Significant cognitive impairment (Mini Mental Status Exam (MMSE))
Interventions
BEHAVIORAL
Mayo Clinic-Approved Education
BEHAVIORAL
Digital Neuropathy
BEHAVIORAL
Capacity Coaching
Conditions
Autosomal Dominant Polycystic Kidney Disease
Locations
Mayo Clinic
Rochester, Minnesota 55905
United States