NCT07751159PHASE2Recruiting

Radiation Therapy Approaches for People With Prostate Cancer

Memorial Sloan Kettering Cancer Center

Start Date

7/31/2026

Completion Date

7/31/2030

Summary

The purpose of the study is to explore the best ways of giving radiation therapy to balance cancer control and treatment side effects.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Non-metastatic prostate cancer. * Classified as unfavorable intermediate-, high-, or very high-risk prostate cancer according to NCCN risk stratification guidelines. (Note: cT3a or T3b by MRI or PSMA PET allowed) * Considered by the treating radiation oncologist as a suitable candidate for both HDR brachytherapy boost and SBRT Exclusion Criteria: * None

Interventions

RADIATION

Standard of Care HDR Brachytherapy

RADIATION

SBRT

Interested in This Trial?

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Conditions

Prostate Cancer PatientsNon-metastatic Prostate CancerHigh Risk Prostate Cancer

Locations

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey 07920

United States

Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)

Middletown, New Jersey 07748

United States

Memorial Sloan Kettering at Bergen (Limited Protocol Activities)

Montvale, New Jersey 07645

United States

Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)

Commack, New York 11725

United States

Memorial Sloan Kettering at Westchester (Limited Protocol Activities)

Harrison, New York 10604

United States

Memorial Sloan Kettering Cancer Center (All Protocol Activites)

New York, New York 10065

United States

Memorial Sloan Kettering at Nassau (Limited Protocol Activities)

Uniondale, New York 11553

United States