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NCT07777926PHASE4RecruitingAccepts Healthy Volunteers

Evaluation of Filler Injection for Chin Profile Enhancement

University of Pennsylvania

Start Date

9/30/2026

Completion Date

12/1/2026

Summary

The goal of this prospective study is to analyze volumetric changes in the lower face after hyaluronic acid filler injections over 90 days. The primary aim of the study is to quantify volume change of the lower face rea over time after injection of filler. The secondary aim is to collect patient related outcomes (PROs) via FACE-Q. Participants will receive hyaluronic acid filler injections (Restylane Lyft(for contouring of the chin. Each patient will receive FDA approved dosages of filler to the lower face region to treat chin regression or chin contouring, as per FDA approved indications. Prior to injections patients will be imaged with 3-dimensional photogrammetry. Subjects will return post-injection in 2 weeks, 1 month, and 3 moths for re-imaging.

Eligibility Criteria

Age Range: 22 years to 55 years

Inclusion Criteria: * Age 22-55 * Patients interested in chin profile enhancement. * Participants must sign the informed consent form. Exclusion Criteria: * Prior filler for facial contouring * Filler injection within the past 12 months or during duration of study * Prior facial cosmetic surgery (i.e.. facelift) * Prior facial trauma (i.e.. orbital fracture) * Pregnant or breastfeeding at the time of injection (initial visit) * Planned dental work within next 2 weeks * The following contraindications: patients with known hypersensitivity or severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies, gram-positive bacterial protein allergies, lidocaine allergies or other local anesthetics of the amide type * Patients with known bleeding disorders

Interventions

DRUG

HA Filler

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Conditions

Chin RegressionChin AsymmetryJawline Contour Deficit

Locations

Penn Medicine

Philadelphia, Pennsylvania 19104

United States