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NCT07786467NARecruitingAccepts Healthy Volunteers

Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

Lake Erie College of Osteopathic Medicine

Start Date

9/1/2026

Completion Date

10/1/2027

Summary

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Willing to receive OMT * Willing to receive influenza vaccine * Older than 18 years of age Exclusion Criteria: * Younger than 18 years of age * Pregnancy or lactation * Unwilling to receive the influenza vaccine * Unwilling to receive OMT * Open wounds * Bone fractures * Moderate to severe osteoporosis * Severe COPD * Current/active infections * Mononucleosis infection within past 6 months * Liver cirrhosis * Cancer or metastatic disease * History of DVT, PE, or blood clotting disorder * Individuals taking blood thinning medications, except aspirin * Having a pacemaker or other thoracic medical devices

Interventions

OTHER

Osteopathic Manipulation

OTHER

Osteopathic manipulation

OTHER

Sham

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Conditions

No Disease or Condition is Being Directly StudiedThe Focus of the Study in Healthy Volunteers

Locations

Plaza 38 Medical Offices

Erie, Pennsylvania 16509

United States