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NCT07824583NARecruiting

A Study Evaluating a New Radiation Treatment Workflow (NGDS)

Varian, a Siemens Healthineers Company

Start Date

7/31/2026

Completion Date

5/1/2027

Summary

The purpose of this research is to evaluate the "Next Generation Delivery System" (NGDS) and determine if this machine will be more efficient at delivering radiation in shorter treatment time and better patient tolerance, with less breath holding.

Detailed Description

This study is a prospective multi-center clinical trial. It is designed to evaluate the feasibility of a breath hold workflow on a new treatment platform (NGDS DMAT). Eligible participants will be receiving stereotactic body radiotherapy (SBRT) under breath hold conditions to targets in the thorax and upper abdomen as part of their routine care. Enrolled participants will be asked to undergo a mock treatment on this new treatment platform under breath hold conditions. Participant images for set up and alignment will be obtained on the NGDS.

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: 1. Target lesions in the thorax or upper abdomen 2. Planned to undergo SBRT radiation treatment delivered on a conventional "C-arm" or ring gantry CBCT guided linear accelerator under breath hold conditions 3. ECOG performance status 0-1 4. At least 21 years of age 5. Able to sign informed consent Exclusion Criteria: 1. Participants enrolled in another clinical investigation the investigator believes to be in conflict with this clinical investigation. 2. Participants with any other medical condition or laboratory value that would, at the discretion of the investigator, preclude the patient from participation in this clinical investigation.

Interventions

DEVICE

Next Generation Delivery System (NGDS)

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Conditions

Lung Cancer (Diagnosis)Liver Cancer, AdultPancreatic CancerThoracic CancersAbdominal Cancer

Locations

Siteman Cancer Center Washington University

St Louis, Missouri 63108

United States

University Hospital Cleveland Medical Center

Cleveland, Ohio 44106

United States