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Maternal Newborn Health Registry

NICHD Global Network for Women's and Children's Health

Start Date

5/1/2008

Completion Date

5/1/2030

Summary

The primary purpose of this population-based study is to quantify and understand the trends in pregnancy outcomes in defined low-resource geographic areas over time, in order to provide population-based data on stillbirths, neonatal and maternal mortality.

Detailed Description

The purpose of the Global Network for Women's and Children's Health Research is to develop and test feasible, sustainable interventions to improve the outcome of women and children and to develop research capacity in resource-poor settings. Because most of the sites have weak health care systems, unacceptably high rates of maternal and neonatal mortality and lack birth and death registries, they lack precise data on outcomes and measures of care. Information from a vital registry system will allow the Global Network to document maternal and neonatal mortality, design trials to address the major causes of poor outcome, assess the outcome of our interventions, and ultimately disseminate the results as the basis of public health policy. A sub-study to the Maternal Newborn Health Registry will be conducted to understand the prevalence of COVID-19 among pregnant women, the association between COVID-19 and pregnancy outcomes, and the Knowledge, Attitudes, and Practices of pregnant women related to COVID-19 and its prevention during pregnancy. Women who consent to participation in the MNHR COVID sub-study will provide a blood specimen at or near delivery to be tested for COVID-19 antibodies. Four Global Network sites (Guatemala, Bangladesh, Nagpur India and Pakistan) will also collect and analyze blood specimen from participants during antenatal care visits.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Community-level * Appropriate for long-term registry data collection and the conduct of ongoing Global Network research * At least 300 deliveries per year * Participant-level * Pregnant women intending to deliver within study cluster * Women who deliver within the study cluster * Women who reside in the community but are transferred for care at delivery Exclusion Criteria: * Participant-level * Opt out of consent to include data in the study

Interventions

OTHER

There is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery.

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Conditions

Pregnancy Outcome Trends in Low-resource Geographic Areas

Locations

University of Alabama at Birmingham

Birmingham, Alabama 35233

United States

University of Colorado Denver

Aurora, Colorado 80045

United States

Indiana University School of Medicine

Indianapolis, Indiana 46202-5119

United States

Boston University

Boston, Massachusetts 02115

United States

Columbia University

New York, New York 10032

United States

University of North Carolina

Chapel Hill, North Carolina 27510

United States

Thomas Jefferson University

Philadelphia, Pennsylvania 19107

United States

University of Virgina

Charlottesville, Virginia 22908

United States

ICDDRB

Dhaka, 1212

Bangladesh

Kinshasa School of Public Health

Kinshasa,

Democratic Republic of the Congo

Institute for Nutrition of Central America and Panama (INCAP)

Guatemala City, Departamento de Guatemala 01011

Guatemala

Lata Medical Research Foundation

Nagpur, India

India

KLE Academy of Higher Education and Research

Belagavi, Karnataka

India

The Aga Khan University

Karachi, Pakistan 74800

Pakistan

University Teaching Hospital

Lusaka, Zambia

Zambia