The Effects of Bariatric Surgeries on Glucose Metabolism
Start Date
7/1/2015
Completion Date
8/1/2027
Summary
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
Detailed Description
The purpose of this study is to determine the weight-independent effects of gastric bypass surgery and sleeve gastrectomy surgery on islet cell response after meal ingestion as mediated by hormonal and neural components of the gut. It will also address the differences between the two procedures. Such information will be critical for the development of novel approaches for treatment of diabetes as well as improvement of glycemic effects of gastric bypass and sleeve gastrectomy in patients with partial diabetes remission or relapse after complete remission.
Eligibility Criteria
Age Range: 18 years to 65 years
Interventions
Exendin-(9-39)
Atropine
Conditions
Locations
Texas Diabetes Institute - University Health System
San Antonio, Texas 78207
United States
South Texas Veterans Health Care System
San Antonio, Texas 78229
United States