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NCT03391778PHASE1Recruiting

Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

USWM CT, LLC

Start Date

4/9/2018

Completion Date

4/1/2032

Summary

This trial will evaluate long term safety of participants who have received AdaptImmune (ADP) adoptive cell therapy for up to 15 years following last adoptive cell therapy infusion.

Detailed Description

Participants who received a ADP adoptive cell therapy will be enrolled in this non-therapeutic, multi-center, long term follow-up (LTFU) study and will be followed for up to 15 years post-infusion of lentiviral vector-based adoptive cell therapy. Participants will be monitored for safety following last adoptive cell therapy infusion.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Participants who have received at least one dose of ADP adoptive cell therapy agent. * Participants who have completed ADP sponsored or supported interventional study or have withdrawn from it. * Participants who have completed treatment as part of managed access to a GSK adoptive cell therapy. * Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. * The investigator is responsible for review of medical history. * Capable of giving signed informed consent. Exclusion Criteria: \- None

Interventions

BIOLOGICAL

ADP adoptive cell therapy

Interested in This Trial?

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Conditions

Neoplasms

Locations

Emory University School of Medicine

Atlanta, Georgia 30322

United States

ADP Investigational Site

Baltimore, Maryland 21201

United States

National Cancer Institute - Center for Cancer Research

Bethesda, Maryland 20892

United States

University of Michigan

Ann Arbor, Michigan 48109

United States

Washington University School of Medicine in St. Louis

St Louis, Missouri 63110

United States

Memorial Sloan Kettering Cancer Center - New York

New York, New York 10065

United States

Duke University Medical Center

Durham, North Carolina 27710

United States

Oregon Health and Science University

Portland, Oregon 97239

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center

Pittsburgh, Pennsylvania 15232

United States

University of Texas Southwestern Medical Center

Dallas, Texas 75390

United States

University of Texas MD Anderson Cancer Center

Houston, Texas 77030

United States

Froedtert Hospital

Milwaukee, Wisconsin 53226

United States

Peter MacCallum Cancer Centre

Melbourne, Victoria 3000

Australia

Princess Margaret Cancer Centre

Toronto, Ontario M5G 2M9

Canada

Hôpital Maisonneuve-Rosemont

Montreal, Quebec H1T 2M4

Canada

Klinikum rechts der Isar der Technischen Universität München

Munich, Bavaria 81377

Germany

Uniklinik Köln

Cologne, North Rhine-Westphalia 50937

Germany

Fondazione IRCCS - Istituto Nazionale dei Tumori

Milan, Lombardy 20133

Italy

Antoni Van Leeuwenhoek Ziekenhuis

Amsterdam, 1066 CX

Netherlands

Hospital Universitario Virgen del Rocío

Seville, 41013

Spain

University College London Hospitals NHS Foundation Trust

London, NW1 2PG

United Kingdom

USWM CT Investigational Site

Manchester, M20 4BX

United Kingdom

The Royal Marsden NHS Foundation Trust

Sutton, SM2 5PT

United Kingdom