Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
Start Date
5/21/2018
Completion Date
5/10/2027
Summary
The main purpose of this study is to: * Learn about the safety of ubamatamab and to find out what dose of ubamatamab can be given alone or with cemiplimab to patients with ovarian cancer or cancer of the uterus * The study will also look at the levels of ubamatamab and/or cemiplimab in the body and measure how well the body can remove the study drug(s). This is called pharmacokinetics * The study will also look at any signs that ubamatamab alone or with cemiplimab can treat recurrent advanced ovarian cancer or cancer of the uterus * To find out how safe and tolerable pretreatment is in combination with ubamatamab and to see how well it works to prevent or minimize Cytokine Release Syndrome (CRS)
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Ubamatamab
Cemiplimab
Sarilumab
Tocilizumab
Conditions
Locations
University of Alabama_6th Ave
Birmingham, Alabama 35294
United States
Massachusetts General Hospital
Boston, Massachusetts 02114
United States
Dana Farber / Harvard Cancer Center
Boston, Massachusetts 02215
United States
Mayo Clinic - Rochester
Rochester, Minnesota 55901
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Columbia University Medical Center
New York, New York 10032
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
The Ohio State University Wexner Medical Center
Columbus, Ohio 43210
United States
Stephenson Cancer Center
Oklahoma City, Oklahoma 73104
United States
Sarah Cannon Research Institute
Nashville, Tennessee 37203
United States
Virginia Commonwealth University
Richmond, Virginia 23219
United States
Prince of Wales Hospital
Randwick, New South Wales 2031
Australia
Peter MacCallum Cancer Center
Melbourne, 3000
Australia
Universitair Ziekenhuis Antwerpen
Edegem, Antwerp 2650
Belgium
Grand Hopital de Charleroi
Charleroi, Hainaut 6000
Belgium
UZLeuven
Leuven, Vlaams-Brabant 3000
Belgium
Hopital Lyon Sud
Pierre-Bénite, Auvergne-Rhône 69310
France
Centre Georges Francois Leclerc
Dijon, Bourgogne-Franche-Comté 21000
France
Institut Bergonie
Bordeaux, New Aquitaine 33076
France
Centre Francois Baclesse (CFB)
Caen, Normandy 14076
France
Centre Antoine Lacassagne
Nice, Provence Alpes Cote dAzur 06189
France
Institut Gustave Roussy
Villejuif, Île-de-France Region 94800
France
Rambam Health Care Campus
Haifa, 3109601
Israel
Sharet Institute of Oncology
Jerusalem, 9112001
Israel
Sheba Medical Center
Tel Litwinsky, 5265601
Israel
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio 00168
Italy
Humanitas S. Pio X
Milan, 20159
Italy
Istituto Europeo di Oncologia
Milan, 20141
Italy
Instituto Nazionale Tumori- Fondazione Pascale
Naples, 80131
Italy
Radboudumc
Nijmegen, Gelderland 6500HB
Netherlands
Erasmus MC
Rotterdam, South Holland 3000 DR
Netherlands
University Medical Center Groningen
Groningen, 9713 GZ
Netherlands
Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center, Univ. of Ulsan
Seoul, 05505
South Korea
Samsung Medical Center
Seoul, 06351
South Korea
Korea University Guro Hospital
Seoul, 08307
South Korea
Seoul National University Hospital
Seoul, 3080
South Korea
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
Institut Catala dOncologia Badalona
Badalona, 08916
Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Spain
Institut Catala d'Oncologia
Barcelona, 8908
Spain
Clinica Universidad Navarra (CUN) Madrid
Madrid, 28027
Spain
Fundacion Jimenez Diaz
Madrid, 28040
Spain
Hospital Universitario San Carlos
Madrid, 28040
Spain
Hospital Clinico Universitatio Santiago de Compostela
Santiago de Compostela, 15706
Spain
University of Oxford
Oxford, Oxfordshire OX1 2JD
United Kingdom
Royal Marsden Hospital - Sutton
Sutton, Surrey SM2 5PT
United Kingdom
The Royal Marsden NHS Foundation Trust
Sutton, Surrey SM2 5PT
United Kingdom
University College London Hospitals
London, NW1 2PG
United Kingdom
Guys Hospital
London, SE1 9RT
United Kingdom
Imperial College Healthcare NHS Trust
London, W12 0HS
United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX
United Kingdom