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NCT03877796Recruiting

Clinical Pre-screening Protocol for Ovarian Cancer

Allarity Therapeutics

Start Date

4/11/2019

Completion Date

12/1/2027

Summary

The patient's local archival tumor tissue (FFPE) from original tumor, or from the metastatic tissue, will be collected to potentially identify if they - at a later stage of their disease - will be likely to benefit from treatment with any of the investigational cancer drugs available to Allarity Therapeutics. Data from this study can further be used to explore in a retrospective fashion, sensitivity to other chemotherapeutic drugs previously used in the treatment of their ovarian cancer, to investigate whether or not the DRP® method can predict and confirm the obtained sensitivity to the prior given drugs as well as prospective analyses guiding the Investigators on future treatments.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Patients with histological confirmed epithelia ovarian cancer * Patients must have platinum-resistant disease, defined as progression within 6 months after the last dose of platinum-based chemotherapy, or are platinum ineligible. * Patients have received no more than one prior line of therapy in the platinum resistant or platinum ineligible setting * FFPE tumor tissue available Exclusion Criteria: * Patients who have platinum-refractory disease, defined as progression during the last platinum-based chemotherapy. * Other malignancy with exception of any stage I and II cancer that is deemed cured by the Investigator

Interventions

DEVICE

Drug Response Predictor® (DRP)

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Conditions

Ovarian Cancer

Locations

Moffitt Cancer Center

Tampa, Florida 33612

United States

Emory Winship Cancer Institute

Atlanta, Georgia 30322

United States

University of New Mexico Comprehensive Cancer

Albuquerque, New Mexico 87131

United States

The Blavatnik Family-Chelsea Medical Center at Mount Sinai

New York, New York 10011

United States

OU Health Stephenson Cancer Center

Oklahoma City, Oklahoma 73104

United States

University Medical Center Cancer Center

Lubbock, Texas 79415

United States

Swedish Center for Research and Innovation

Seattle, Washington 98122

United States

Beatson West of Scotland Cancer Centre

Glasgow, Scotland G12 0YN

United Kingdom

Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital

London,

United Kingdom