A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
Start Date
1/7/2020
Completion Date
4/22/2032
Summary
This study will evaluate REGN5093 for the treatment of Non-Small Cell Lung Cancer (NSCLC) with MET alteration. The main purpose of this study is to determine the safety, tolerability, and effectiveness of REGN5093. The study has two phases. The main goal of Phase 1 is to determine a safe dose(s) of REGN5093. The main goal of phase 2 of the study is to use the REGN5093 drug dose(s) found in Phase 1 to see how well REGN5093 works to shrink tumors. The study is looking at several other research questions, including: * Side effects that may be experienced by people taking REGN5093 * How REGN5093 works in the body * How much REGN5093 is present in the blood * To see if REGN5093 works to reduce or delay the progression of cancer * How long it takes REGN5093 to work in the body
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
REGN5093
Conditions
Locations
University of Alabama at Birmingham
Birmingham, Alabama 35294
United States
University of California Irvine Medical Center - Bldg 56, RT81, Rm 241
Orange, California 92868
United States
Georgetown University Medical Center
Washington D.C., District of Columbia 20007
United States
Moffitt Cancer Center - McKinley Drive
Tampa, Florida 33612
United States
University of Kentucky, Markey Cancer Center Clinical Research Organization
Lexington, Kentucky 40536
United States
DNU_Massachusetts General Hospital_DNU
Boston, Massachusetts 02114
United States
Dana Farber Harvard Cancer Center Consortium
Boston, Massachusetts 02215
United States
Henry Ford Health System
Detroit, Michigan 48202
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
NYU Cancer Institute
New York, New York 10016
United States
Icahn School of Medicine at Mount Sinai
New York, New York 10029
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Duke Cancer Center
Durham, North Carolina 27710
United States
Stephenson Cancer Center
Oklahoma City, Oklahoma 73104
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
University of Pittsburgh UPMC - Clinical Research Services
Pittsburgh, Pennsylvania 15232
United States
Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas 75235
United States
The University of Texas MD Anderson Cancer Center
Houston, Texas 77030
United States
Centre Georges Francois Leclerc
Dijon, Bourgogne-Franche-Comté 21034
France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
Rennes, Bretange 35033
France
Institut Bergonie
Bordeaux, New Aquitaine 33076
France
Centre Francois Baclesse (CFB)
Caen, Normandy 14076
France
Centre Hospitalier Universitaire de Grenoble
Grenoble, 38043
France
Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve
Montpellier, 34295
France
National Cancer Center
Gyeonggi-do, Gyeonggi-do 10408
South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
The Catholic University Of Korea St. Vincent's Hospital
Suwon, Gyeonggi-do 16247
South Korea
Ajou University Hospital
Suwon, Gyeonggi-do 16499
South Korea
Haeundae Paik Hospital
Pusan, Gyeongsangnam-do 48108
South Korea
Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do 58128
South Korea
Gachon University Gil Medical Center
Incheon, Namdong-gu 21565
South Korea
Chungbuk National University Hospital
Cheongju-si, North Chungcheong 28644
South Korea
Pusan National University Hospital
Busan, 49241
South Korea
Severance Hospital Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Samsung Medical Center
Seoul, 06351
South Korea
Seol St. Mary's Hospital
Seoul, 06591
South Korea
Boramae Medical Center
Seoul, 07061
South Korea
Korea University Guro Hospital
Seoul, 08308
South Korea
Seoul National University Hospital
Seoul, 3080
South Korea