NCT04838678EARLY_PHASE1RecruitingAccepts Healthy Volunteers

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

University of Texas Southwestern Medical Center

Start Date

7/18/2021

Completion Date

8/31/2026

Summary

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Eligibility Criteria

Age Range: 18 years to 55 years

Inclusion Criteria: * Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Exclusion Criteria: All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Interventions

DRUG

Neuropeptide Y

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

HypertensionObesity

Locations

University of Texas Southwestern Medical Center

Dallas, Texas 75231

United States