NCT04906759NARecruiting

Meal Delivery and Exercise

The University of Texas Health Science Center, Houston

Start Date

7/19/2021

Completion Date

2/28/2026

Summary

The purpose of this study is to evaluate the effects of a home-based exercise program administered through Meals on wheels (MOW) on gait speed and frailty status and to assess the association between novel serum biomarkers (70 kilodalton heat shock proteins (HSP70),Macrophage Inflammatory Proteins(MIP1b), soluble IL-6 receptor alpha-chain (sIL-6R)) and established but non-specific frailty biomarkers (Interleukin 6 (IL-6), C-reactive protein (CRP), Tumor necrosis factor (TNF-α)) in frail and prefrail homebound older adults before and after the exercise intervention.

Eligibility Criteria

Age Range: 60 years to No maximum

Inclusion Criteria: * homebound (normally unable to leave the home unassisted) * frail or prefrail by The Fried Frailty Phenotype (FFP) * medically stable Exclusion Criteria: * robust by FFP * have Mini-Cog score \<3 and/or are unable to follow instructions * have a pre-diagnosed terminal illness * unable to ambulate * unable to use their upper extremities, and/or are already participating in physician-prescribed physical therapy or occupational therapy.

Interventions

BEHAVIORAL

Meals plus exercise

BEHAVIORAL

Meals only

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Conditions

Frailty

Locations

The University of Texas Health Science Center at Houston

Houston, Texas 77030

United States