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NCT04949451NARecruitingAccepts Healthy Volunteers

Time Restricted Feeding, Muscle, and Metabolism

University of Arkansas, Fayetteville

Start Date

6/13/2021

Completion Date

12/30/2025

Summary

Effective nutrition strategies for combatting and/or preventing obesity still need to be identified. This has been the case despite the numerous and different approaches that have been taken. Potential targets for combatting/preventing obesity have been identified, but long-term solutions have not emerged. This study uses time restricted feeding to study the role of dietary protein in obesity prevention and/or treatment. The objectives are to determine the role of skeletal muscle mass as a driver of energy-sensing mechanisms and peripheral signals that regulate appetite and energy intake in overweight and obese adults and to determine the effects of protein timing on muscle mass to regulate appetite and energy intake in overweight and obese adults.

Eligibility Criteria

Age Range: 25 years to 50 years

Inclusion Criteria: * Resides in Northwest Arkansas * Age 25-50 years * BMI \> 25 * All ethnicities * Female and male Exclusion Criteria: * Food allergies * Pregnant or breastfeeding * Dietary restrictions (e.g. vegetarian, vegan, etc.) * Trying to lose weight in last 3 months * Pre-existing health conditions related to obesity (e.g. cardiovascular disease, diabetes, hypertension) * Prescription medications related to heart disease or type 2 diabetes * Fear of needles * Smoker or vaping * Currently taking protein supplements or other nutritional supplements which may interfere with study outcomes * Consumes \>4 alcoholic beverages per week

Interventions

DIETARY_SUPPLEMENT

Whey protein supplement

DIETARY_SUPPLEMENT

Ketogenic aid

OTHER

Control group - time restricted feeding only

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Conditions

OverweightObesity

Locations

University of Arkansas

Fayetteville, Arkansas 72704

United States