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NCT07595549PHASE3Recruiting

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

Pfizer

Start Date

6/10/2026

Completion Date

6/21/2028

Summary

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Aged ≥18 years. * BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to \<30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D. Exclusion Criteria: * Have a self-reported body weight change greater than 5% within 90 days prior to Screening. * Diagnosis of type 1 diabetes or any other form of diabetes other than T2D. * History of acute or chronic pancreatitis. * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).

Interventions

DRUG

PF-08653944

OTHER

Placebo

Interested in This Trial?

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Conditions

ObesityOverweight and/or ObesityOverweight

Locations

ImmuniMet, LLC

Modesto, California 95350

United States

ClearVue Eye Care

Roseville, California 95661

United States

Clinical Trials Research

Sacramento, California 95821

United States

University Clinical Investigators, Inc.

Tustin, California 92780

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Nature Coast Clinical Research

Crystal River, Florida 34429

United States

West Coast Eye Institute

Lecanto, Florida 34461

United States

South Broward Research

Miramar, Florida 33027

United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida 34652

United States

West Coast Medical Associates

New Port Richey, Florida 34652

United States

MediSphere Medical Research Center, LLC

Evansville, Indiana 47714

United States

Monroe Biomedical Research

Louisville, Kentucky 40213

United States

Aa Mrc Llc

Flint, Michigan 48504

United States

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico 87102

United States

Rochester Clinical Research, LLC

Rochester, New York 14609

United States

Medication Management LLC

Greensboro, North Carolina 27405

United States

Midwest Eye Center

Cincinnati, Ohio 45202

United States

Velocity Clinical Research, Mt. Auburn

Cincinnati, Ohio 45219

United States

VIP Trials

San Antonio, Texas 78230

United States

York Clinical Research, LLC

Norfolk, Virginia 23504

United States

Medical Corporation Heishinkai OCROM Clinic

Suita, Osaka 565-0853

Japan

Tokyo Center Clinic

Chuo-ku, Tokyo 103-0027

Japan

Tokyo-Eki Center-Building Clinic

Chuo-ku, Tokyo 103-0027

Japan

Fukuwa Clinic

Chuo-ku, Tokyo 104-0031

Japan

Medical Corporation Heishinkai ToCROM Clinic

Shinjuku-ku, Tokyo 160-0008

Japan