A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
Start Date
10/4/2021
Completion Date
5/31/2027
Summary
The purpose of this clinical trial is to (1) learn whether the BCMA-CD3 bispecific antibody elranatamab can provide more benefit to people with multiple myeloma compared to a combination therapy including daratumumab, pomalidomide, and dexamethasone, and (2) learn about the safety and activity of elranatamab in combination with the anti-CD38 monoclonal antibody daratumumab. People with multiple myeloma who have received previous treatment including lenalidomide will be enrolled in the study. Part 1 of the study will assess the safety and activity of different doses of elranatamab in combination with daratumumab. People participating in Part 2 of the study will be randomly assigned to receive either elranatamab alone, elranatamab plus daratumumab, or daratumumab, pomalidomide, and dexamethasone. Part 2 will evaluate the safety and activity of (1) elranatamab alone compared to daratumumab, pomalidomide, and dexamethasone, and (2) elranatamab plus daratumumab. Part 3 will assess the effect of increased measures to protect against infection in people treated with either elranatamab alone or together with daratumumab. All people participating in the study will receive study treatment until their disease progresses, they experience unacceptable side effects, or they choose to no longer participate in the study.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Elranatamab
Daratumumab
Pomalidomide
Dexamethasone
Conditions
Locations
Clovis Community Medical Center
Clovis, California 93611
United States
Community Cancer Institute
Clovis, California 93611
United States
University of California San Francisco
Fresno, California 93701
United States
Community Regional Medical Center
Fresno, California 93721
United States
UCHealth Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
UCHealth Harmony
Fort Collins, Colorado 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado 80634
United States
UCHealth - Medical Center of the Rockies
Loveland, Colorado 80538
United States
Sylvester Comprehensive Cancer Center - Aventura
Aventura, Florida 33180
United States
Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center
Coral Gables, Florida 33146
United States
Sylvester Comprehensive Cancer Center - Coral Springs
Coral Springs, Florida 33065
United States
University of Miami Hospital and Clinics - Deerfield Beach
Deerfield Beach, Florida 33442
United States
Sylvester Comprehensive Cancer Center - Hollywood
Hollywood, Florida 33021
United States
Sylvester Comprehensive Cancer Center
Miami, Florida 33136
United States
University of Miami Hospital and Clinics
Miami, Florida 33136
United States
Sylvester Comprehensive Cancer Center - Kendall
Miami, Florida 33176
United States
Sylvester Comprehensive Cancer Center - Plantation
Plantation, Florida 33324
United States
East Jefferson General Hospital
Metairie, Louisiana 70006
United States
MSK Basking Ridge
Basking Ridge, New Jersey 07920
United States
MSK Monmouth
Middletown, New Jersey 07748
United States
MSK Bergen
Montvale, New Jersey 07645
United States
MSK Commack
Commack, New York 11725
United States
MSK Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, New York 10021
United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York 10065
United States
MSK Nassau
Uniondale, New York 11553
United States
Alexander Fleming S.A (Instituto Medico Especializado Alexander Fleming)
Ciudad Autonoma de Buenos Aires, Buenos Aires 1426
Argentina
FUNDALEU - Fundacion para combatir la Leucemia
Ciudad Autonoma de Buenos Aires, Buenos Aires C1114AAN
Argentina
FUNDALEU -Fundación para combatir la leucemia
Ciudad Autónoma de Buenos Aires, Buenos Aires C1114AAP
Argentina
FUNDALEU
Ciudad Autónoma de Buenos Aires, Buenos Aires C1114AAP
Argentina
Hospital Italiano de La Plata
La Plata, Buenos Aires B1900XI
Argentina
Hospital Universitario Austral
Presidente Derqui, Buenos Aires B1629AHJ
Argentina
Sanatorio de La Mujer
Rosario, Santa Fe Province S2000ORE
Argentina
Pindara Private Hospital
Benowa, Queensland 4217
Australia
QScan Radiology Clinics
Clayfield, Queensland 4011
Australia
Gallipoli Medical Research Foundation
Greenslopes, Queensland 4120
Australia
Greenslopes Private Hospital
Greenslopes, Queensland 4120
Australia
Princess Alexandra Hospital
Woolloongabba, Queensland 4102
Australia
Epworth Freemasons
East Melbourne, Victoria 3002
Australia
St Vincent's Hospital (Melbourne)
Fitzroy, Victoria 3065
Australia
Barwon Health
Geelong, Victoria 3220
Australia
The Alfred Hospital
Melbourne, Victoria 3004
Australia
Epworth Healthcare
Richmond, Victoria 3121
Australia
Slade Pharmacy
Richmond, Victoria 3121
Australia
Linear Clinical Research
Perth, Western Australia 6009
Australia
Universitätsklinikum Krems
Krems, Lower Austria 3500
Austria
Klinik Ottakring
Vienna, State of Vienna 1160
Austria
Universitätsklinik für Innere Medizin V Innsbruck
Innsbruck, 6020
Austria
Uniklinikum Salzburg
Salzburg, 5020
Austria
Medizinische Universität Wien
Vienna, 1090
Austria
Grand Hôpital de Charleroi
Gilly, Hainaut 6060
Belgium
CHU UCL Namur (site Godinne)
Yvoir, Namur 5530
Belgium
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, Estado de Bahia 41253-190
Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Porto Alegre, Rio Grande do Sul 90110-270
Brazil
Centro de Pesquisa Clínica - Área Administrativa
Porto Alegre, Rio Grande do Sul 90850-170
Brazil
Hospital Mae de Deus
Porto Alegre, Rio Grande do Sul 90880-480
Brazil
BP - A Beneficencia Portuguesa de São Paulo
São Paulo, São Paulo 01321-001
Brazil
Clínica Médica São Germano LTDA
SP, São Paulo 04537-080
Brazil
Hospital Américas Medical City
Rio de Janeiro, 22775001
Brazil
Instituto de Educação, Pesquisa e Gestão em Saúde
Rio de Janeiro, 22793-080
Brazil
ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de Higienópolis
São Paulo, 01232-010
Brazil
IDOR Ensino e Pesquisa
São Paulo, 01401-002.
Brazil
HU UNIFESP / SPDM - Hospital São Paulo
São Paulo, 04024-002
Brazil
Universidade Federal de Sao Paulo
São Paulo, 04024-002
Brazil
Clínica Médica São Germano S/S Ltda
São Paulo, 04537-080
Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04543-000
Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04544-000
Brazil
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta T2N 5G2
Canada
Cross Cancer Institute
Edmonton, Alberta T6G 1Z2
Canada
QEII Health Sciences Centre - Victoria General Site
Halifax, Nova Scotia B3H 2Y9
Canada
Hamilton Health Sciences-Juravinski Cancer Centre
Hamilton, Ontario L8V5C2
Canada
Princess Margaret Cancer Centre
Toronto, Ontario M5G 2M9
Canada
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec H1T2M4
Canada
Jewish General Hospital
Montreal, Quebec H3T 1E2
Canada
Saskatoon Cancer Center
Saskatoon, Saskatchewan S7N4H4
Canada
Peking University Third Hospital
Beijing, Beijing Municipality 100191
China
Fujian Medical University Union Hospital
Fuzhou, Fujian 350001
China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong 510080
China
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong 510515
China
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong 510555
China
Shenzhen Second People's Hospital
Shenzhen, Guangdong 518035
China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei 050000
China
Henan Cancer Hospital
Zhengzhou, Henan 450008
China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei 430030
China
Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu 210008
China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu 221006
China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330006
China
Jilin Province Cancer Hospital
Changchun, Jilin 130000
China
The First Hospital of Jilin University
Changchun, Jilin 130021
China
Shandong Provincial Hospital
Jinan, Shandong 250021
China
Jinan Central Hospital
Jinan, Shandong 250100
China
Institute of hematology&blood disease hospital
Tianjin, Tianjin Municipality 301636
China
The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang 310003
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang 325000
China
Beijing Boren Hospital
Beijing, 100070
China
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing, 100730
China
Chongqing University Cancer Hospital
Chongqing, 400030
China
Fakultní nemocnice Brno Bohunice
Brno, Brno-m?sto 625 00
Czechia
Fakultni Nemocnice Plzen
Plzen - Lochotin, Plzeň Region 304 60
Czechia
Fakultni poliklinika
Prague, Praha 2 120 00
Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Czechia
Fakultni nemocnice Olomouc
Olomouc, 779 00
Czechia
Fakultni nemocnice Ostrava
Ostrava-Poruba, 708 52
Czechia
Vseobecna fakultni nemocnice v Praze
Prague, 12808
Czechia
Kuopion Yliopistollinen Sairaala
Kuopio, Northern Savonia 70210
Finland
Tampereen yliopistollinen sairaala
Tampere, Pirkanmaa 33520
Finland
Turku University Hospital
Turku, Southwest Finland 20520
Finland
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
Helsinki, 00029
Finland
Oulun yliopistollinen sairaala
Oulu, 90220
Finland
Tampereen yliopistollinen sairaala
Tampere, 33520
Finland
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges, Limousin 87042
France
Hopital Claude Huriez - CHU de Lille
Lille, NORD 59000
France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
Nantes, 44093
France
Hopital Necker
Paris, 75015
France
Hôpital Saint Antoine
Paris, 75571
France
Centre Hospitalier Lyon Sud - Service d'Hematologie Clinique
Pierre-Bénite, 69495
France
CHU de Poitiers, Hôpital de la Milétrie, Pôle Régional de Cancérologie
Poitiers, 86021
France
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE
Toulouse, 31059
France
Universitaetsklinikum Ulm
Ulm, Baden-Wurttemberg 89081
Germany
Universitätsklinikum Würzburg
Würzburg, Bavaria 97080
Germany
Charité Universitätsmedizin Berlin
Berlin, 12203
Germany
Staedtisches Klinikum Braunschweig gGmbH
Braunschweig, 38114
Germany
Klinikum Chemnitz gGMbH
Chemnitz, 09116
Germany
Universitätsklinikum rechts der Isar, Technische Universität München (TUM)
München, 81675
Germany
Evangelismos General Hospital of Athens
Athens, Attikí 106 76
Greece
Radiology vendor
Athens, Attikí 115 25
Greece
Alexandra General Hospital of Athens
Athens, Attikí 115 28
Greece
Theageneio Cancer Hospital of Thessaloniki
Thessaloniki, Kentrikí Makedonía 546 39
Greece
University General Hospital of Ioannina
Ioannina,
Greece
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna 47014
Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Lombardy 20122
Italy
Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy 20900
Italy
ASST Santi Paolo e Carlo Ospedale San Carlo Borromeo SSD di Onco-Ematologia (Edificio C-piano terra)
Milan, Milan 20153
Italy
Policlinico "G. Rodolico"
Catania, Sicily 95123
Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Italy
IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM)
Genova, 16132
Italy
AOU Policlinico Umberto I
Roma, 00161
Italy
Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168
Italy
Nagoya City University Hospital
Nagoya, Aichi-ken 467-8602
Japan
University of Fukui Hospital
Yoshida-gun, Fukui 910-1193
Japan
National Hospital Organization Shibukawa Medical Center
Shibukawa, Gunma 377-0280
Japan
Iwate Medical University Hospital
Yahaba-cho, Iwate 028-3695
Japan
Tohoku University Hospital
Sendai, Miyagi 980-8574
Japan
Shizuoka Cancer Center
Sunto-gun, Shizuoka 411-8777
Japan
Japanese Red Cross Medical Center
Shibuya-ku, Tokyo 150-8935
Japan
Akita University Hospital
Akita, 010-8543
Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395
Japan
Kagoshima University Hospital
Kagoshima, 890-8520
Japan
National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008
Japan
Nagasaki University Hospital
Nagasaki, 852-8501
Japan
National Hospital Organization Okayama Medical Center
Okayama, 701-1192
Japan
Osaka Metropolitan University Hospital
Osaka, 545-8586
Japan
Tokushima University Hospital
Tokushima, 770-8503
Japan
Yamagata University Hospital
Yamagata, 990-9585
Japan
Hematológica Alta Especialidad SC, consultorio 830
Colonia Valle de Las Palmas, México 52787
Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León 66460
Mexico
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, 68020
Mexico
Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, 91851
Mexico
Erasmus Universitair Medisch Centrum
Rotterdam, South Holland 3015 GD
Netherlands
Maastricht University Medical Center
Maastricht, 6229 HX
Netherlands
North Shore Hospital
Auckland, 0622
New Zealand
Labtests Auckland Ltd.
Auckland, 1060
New Zealand
Aotearoa Clinical Trials
Auckland, 2025
New Zealand
Waikato District Health Board, Waikato Hospital
Hamilton, 3204
New Zealand
TRG Imaging
Milford, 0620
New Zealand
Pacific Radiology
Newtown, 6021
New Zealand
Broadway Radiology
Palmerston North, 4410
New Zealand
Palmerston North Hospital
Roslyn, 4414
New Zealand
Pharmacy on Shakespeare
Takapuna, 0620
New Zealand
Capital, Coast and Hutt Valley District - Wellington Regional Hospital
Wellington, 6021
New Zealand
Haukeland Universitetssjukehus
Bergen, Hordaland 5021
Norway
Stavanger Universitetssykehus
Stavanger, Rogaland 4021
Norway
Oslo Universitetssykehus Ullevål
Oslo, 0450
Norway
St Olavs Hospital
Trondheim, 7030
Norway
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy Klinika Hematologii
Bydgoszcz, 85-168
Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-214
Poland
Pratia Onkologia Katowice
Katowice, 40-519
Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, 60-569
Poland
Centrum Medyczne Pratia Poznan
Skorzewo, 60-185
Poland
Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital Kliniczny
Warsaw, 02-097
Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
Wroclaw, 50-367
Poland
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Chonnam National University Hwasun Hospital
Hwasun-gun, Jeonranamdo 58128
South Korea
Pusan National University Hospital
Busan, Pusan-kwangyǒkshi 49241
South Korea
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul] 03080
South Korea
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul] 06351
South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul-teukbyeolsi [seoul] 06591
South Korea
Kyungpook National University Hospital
Daegu, Taegu-kwangyǒkshi 41944
South Korea
Gachon University Gil Medical Center
Incheon, 21565
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Complejo Hospitalario Universitario de Santiago
Santiago de Compostela, A Coruna 15706
Spain
Institut Català d'Oncologia - L'Hospitalet
L'Hospitalet Del Llobregat, Barcelona [barcelona] 08908
Spain
Hospital Universitari Mutua Terrassa
Terrassa, Barcelona 08221
Spain
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria 39008
Spain
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitario de Toledo
Toledo, Other 45007
Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Spain
Hospital Clinic Barcelona
Barcelona, 08036
Spain
Hospital Universitari De Girona Doctor Josep Trueta
Girona, 17007
Spain
Hospital Universitario La Princesa
Madrid, 28006
Spain
Hospital Universitario Madrid Sanchinarro
Madrid, 28050
Spain
Hospital Universitario de Salamanca
Salamanca, 37007
Spain
Hospital Universitario Virgen Del Rocio
Seville, 41013
Spain
Hospital Universitario y Politecnico La Fe
Valencia, 46026
Spain
Skånes Universitetssjukhus Lund
Lund, Skåne LÄN [se-12] 22185
Sweden
Södra Älvsborg Sjukhus
Borås, 501 82
Sweden
Falu Lasarett
Falun, 791 82
Sweden
Sahlgrenska Universitetssjukhuset
Gothenburg, 41345
Sweden
Sunderby Sjukhus
Luleå, 971 80
Sweden
Universitetssjukhuset Örebro
Örebro, Örebro LÄN [se-18] 701 85
Sweden
Läkemedelsberedningen
Linköping, Östergötlands LÄN [se-05] 581 85
Sweden
Universitetssjukhuset i Linköping
Linköping, Östergötlands LÄN [se-05] 581 85
Sweden
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung City, 83301
Taiwan
China Medical University Hospital
Taichung, 40447
Taiwan
National Cheng Kung University Hospital
Tainan, 704
Taiwan
National Taiwan University Hospital
Taipei, 10002
Taiwan
Taipei Veterans General Hospital
Taipei, 11217
Taiwan
Istanbul Universitesi Istanbul Tıp Fakultesi Hastanesi
Istanbul, İ̇stanbul 34093
Turkey (Türkiye)
Medipol Mega Universite Hastanesi
Istanbul, İ̇stanbul 34214
Turkey (Türkiye)
Acibadem Universitesi Atakent Hastanesi
Istanbul, İ̇stanbul 34303
Turkey (Türkiye)
Ege Universitesi Hastanesi
Izmir, İ̇zmir 35100
Turkey (Türkiye)
Dokuz Eylul Universitesi Hastanesi
Izmir, İ̇zmir 35340
Turkey (Türkiye)
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi
Adana, 01240
Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals
Ankara, 06100
Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
Ankara, 06200
Turkey (Türkiye)
Akdeniz Universitesi Hastanesi
Antalya, 07070
Turkey (Türkiye)
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
Gaziantep, 27310
Turkey (Türkiye)
Sisli Florence Nightingale Hastanesi
Istanbul, 34381
Turkey (Türkiye)
Erciyes Universitesi Tıp Fakultesi Hastaneleri
Kayseri, 38030
Turkey (Türkiye)
Özel Anadolu Sağlık Merkezi
Kocaeli, 41400
Turkey (Türkiye)
Inonu Universitesi Turgut Ozal Tıp Merkezi
Malatya, 44280
Turkey (Türkiye)
Royal Bournemouth Hospital
Bournemouth, Dorset BH7 7DW
United Kingdom
Churchill Hospital, Oxford University Hospitals NHS Foundation Trust
Oxford, Oxfordshire OX3 7LE
United Kingdom
University Hospital of Wales
Cardiff, South Glamorgan CF14 4XW
United Kingdom
Bristol Haematology and Oncology Centre
Bristol, BS2 8ED
United Kingdom
Kent and Canterbury Hospital
Canterbury, CT1 3NG
United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX
United Kingdom