Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma
Start Date
6/23/2026
Completion Date
1/31/2033
Summary
The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of care (SOC) in participants with multiple myeloma (MM) who have received one to three prior lines of therapy and have been exposed to an anti-CD38 monoclonal antibody (mAb) and lenalidomide.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Cevostamab
Pomalidomide
Dexamethasone
Daratumumab
Elotuzumab
Carfilzomib
Conditions
Locations
City of Hope National Medical Center
Duarte, California 91010-3012
United States
City of Hope - Lennar Foundation Cancer Center
Irvine, California 92618
United States
Yale University
New Haven, Connecticut 06510
United States
MedStar Washington Hospital Center MedStar Georgetown Cancer Institute
Washington D.C., District of Columbia 20010
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Novant Health Cancer Institute
Charlotte, North Carolina 28215
United States
Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists
Winston-Salem, North Carolina 27103
United States
TriHealth Cancer and Blood Institute
Cincinnati, Ohio 45220
United States
MD Anderson Cancer Center
Houston, Texas 77030-4009
United States
West Virginia University
Morgantown, West Virginia 26506
United States
St Vincent's Hospital Melbourne
Fitzroy, Victoria 3065
Australia
The Alfred Hospital
Melbourne, Victoria 3004
Australia
Hospital Israelita Albert Einstein
São Paulo, São Paulo 05652-000
Brazil
Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton, Ontario L8V 1C3
Canada
Sun yat-sen University Cancer Center
Guangzhou, Guangdong 510555
China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu 210008
China
The Affiliated Hospital Of Qingdao University
Qingdao, Shandong 266003
China
Tianjin Institute of Hematology & Blood Diseases Hospital
Tianjin, Tianjin Municipality 301636
China
The First Affilliated Hospital of Kunming Medical University
Kunming, Yunnan 650032
China
The First Affiliated Hospital, Zhejiang University School of Medicine - Qingchun Campus - PPDS
Hangzhou, Zhejiang 310003
China
Nanfang Hospital, Southern Medical University
Guangzhou, 510515
China
Qilu Hospital of Shandong University
Jinan, 250012
China
The First Affiliate Hospital of Guangxi Medical University
Nanning, 530021
China
Zhongshan Hospital Fudan University
Shanghai, 200032
China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, 200127
China
The First Affiliated Hospital of Soochow University
Suzhou, 215006
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325035
China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430030
China
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Czechia
Fakultni nemocnice Ostrava
Ostrava, 708 52
Czechia
Aarhus Universitetshospital
Aarhus, 8000
Denmark
Rigshospitalet
København Ø, 2100
Denmark
Sygehus Lillebælt, Vejle;Hæmatologisk Forskningsenhed, HKFE
Vejle, 7100
Denmark
CHU de Nantes - Hôtel-Dieu
Nantes, Loire-Atlantique 44093
France
CHRU de Lille - Hopital Claude Huriez
Lille, 59037
France
CHU Lyon - Centre Hospitalier Lyon Sud
Pierre-Benite (Lyon), 69495
France
CHU de Poitiers - La Miletrie
Poitiers, 86021
France
CHU de Toulouse -Service d'Hématologie
Toulouse, 31100
France
HELIOS Klinikum Bad Saarow
Bad Saarow, 15526
Germany
Vivantes Klinikum Am Urban Klinik für Innere Medizin Hämatologie und Onkologie
Berlin, 10967
Germany
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin
Berlin, 12200
Germany
Marien-Hospital Klinik f.Hämatologie Onkologie u.Palliativmedizin
Düsseldorf, 40479
Germany
Universitätsklinikum Frankfurt
Frankfurt, 60590
Germany
Universitätsmedizin Greifswald
Greifswald, 17475
Germany
UKSH, Campus Kiel
Kiel, 24105
Germany
Evangelismos General Hospital of Athens
Athens, 106 76
Greece
Alexandras General Hospital of Athens
Athens, 11528
Greece
Anticancer Hospital of Thessaloniki " Theagenio"
Thessaloniki, 540 07
Greece
Rambam Health Care Campus
Haifa, 31096
Israel
Hadassah Ein Karem Hospital
Jerusalem, 9112001
Israel
Chaim Sheba Medical Center
Ramat Gan, 5266200
Israel
Ichilov Sourasky Medical Center
Tel Aviv, 6423906
Israel
Policlinico S.Orsola-Malpighi
Bologna, Emilia-Romagna 40138
Italy
IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"
Meldola, Emilia-Romagna 47014
Italy
Asst Papa Giovanni Xxiii
Bergamo, Lombardy 24127
Italy
Istituto Clinico Humanitas
Rozzano, Lombardy 20089
Italy
AOU Città della Salute e della Scienza di Torino - Presidio Le Molinette
Turin, Piedmont 10126
Italy
Toyohashi Municipal Hospital
Toyohashi, Aichi-ken 441-8570
Japan
Nagoya City University Hospital
Aichi, 467-8602
Japan
Matsuyama Red Cross Hospital
Ehime, 790-8524
Japan
Gunma University Hospital
Gunma, 371-8511
Japan
Hyogo Medical University Hospital
Hyōgo, 663-8501
Japan
University Hospital Kyoto Prefectural University of Medicine
Kyoto, 602-8566
Japan
Iwate Medical University Hospital
Numakunai, 028-3695
Japan
National Hospital Organization Okayama Medical Center
Okayama, 701-1192
Japan
Osaka University Hospital
Osaka, 565-0871
Japan
Dokkyo Medical University Saitama Medical Center
Saitama, 343-8555
Japan
Japanese Red Cross Medical Center
Shibuya-ku, 150-8935
Japan
The Cancer Institute Hospital of JFCR
Tokyo, 135-8550
Japan
Yamagata University Hospital
Yamagata, 990-9585
Japan
SP ZOZ Szpital Uniwersytecki w Krakowie-Jakubowskiego 2;Oddzial Kliniczny Hematologii
Krakow, Lesser Poland Voivodeship 30-688
Poland
Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214
Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
Późna, 60-569
Poland
SP Szpital Kliniczny nr 1 Pomorskiej Akademii Medycznej im. prof. Tadeusza Sokolowskiego
Szczecin, 71-252
Poland
Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy
Warsaw, 02-721
Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
Wroc?aw, 50-367
Poland
Auxilio Mutuo Cancer Center
San Juan, 917
Puerto Rico
Chonnam National University Hwasun Hospital
Jeollanam-do, 58128
South Korea
Seoul National University Hospital
Seoul, 03080
South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Samsung Medical Center
Seoul, 06351
South Korea
Seoul St Mary's Hospital
Seoul, 06591
South Korea
Institut Catala d?Oncologia Hospital Germans Trias i Pujol
Badalona, Barcelona 08916
Spain
Hospital Costa del Sol
Marbella, Malaga 29603
Spain
Clinica Universitaria de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Spain
Hospital Clinic i Provincial de Barcelona
Barcelona, 08036
Spain
Hospital General Universitario Gregorio Marañon
Madrid, 28009
Spain
Hospital Clinico Universitario de Salamanca
Salamanca, 37007
Spain
University College London Hospitals NHS Foundation Trust
London, W1T 7HA
United Kingdom
Oxford Churchill Hospital
Oxford, OX3 7LE
United Kingdom
The Royal Wolverhampton Hospitals NHS Trust
Wolverhampton, WV10 0QP
United Kingdom