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NCT05108519Recruiting

Complications and Clinical Response in Cancer Patients Treated With Anti-VEGF-Related Therapies

M.D. Anderson Cancer Center

Start Date

4/8/2019

Completion Date

2/2/2027

Summary

This study collects information about complications and clinical response in cancer patients treated with anti-VEGF-related therapies. This study aims to observe side effects that may happen to patients with advanced cancer who are treated with anti-VEGF related therapy. This may help doctors learn if there are any relationships between these side effects and how the disease may respond to treatment.

Detailed Description

PRIMARY OBJECTIVE: I. To explore the incidence of clinical complications associated with anti-VEGF-related therapies in cancer patients treated at Emory University and the University of Texas M.D. Anderson Cancer Center (MDACC). SECONDARY OBJECTIVES: I. To explore the correlation of clinical response rates to a novel blood pressure scoring system in cancer patients treated with anti-VEGF-related therapies. II. To explore the correlation of objective response to each toxicity grade 3 or higher in cancer patients treated with anti-VEGF-related therapies. III. To investigate the validity of a novel multi-parameter-based blood pressure scoring system and to determine if the new scoring method is concordant with the current Common Terminology Criteria for Adverse Events (CTCAE) method. OUTLINE: Patients' medical records are reviewed.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Patients must be able to understand and be willing to sign a written informed consent document * Patients must be receiving any anti-VEGF-related regimen in monotherapy or combination therapy

Interventions

OTHER

Electronic Health Record Review

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Conditions

Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm

Locations

M D Anderson Cancer Center

Houston, Texas 77030

United States