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NCT05193968NARecruitingAccepts Healthy Volunteers

Hot Flashes and Neurovascular Function in Women

Mayo Clinic

Start Date

2/24/2022

Completion Date

12/1/2026

Summary

Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.

Eligibility Criteria

Age Range: 40 years to 60 years

Inclusion Criteria: * Non-smokers. * Non-obese. * Have at least one ovary. * Free from cardiovascular disease. * Not taking medications influencing cardiovascular function. Exclusion Criteria: \- None.

Interventions

OTHER

Sympathoexcitatory stressors

DRUG

Sodium Nitroprusside

DRUG

Acetylcholine

DRUG

Terbutaline

DRUG

Norepinephrine

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Conditions

Hot FlashesMenopauseVasomotor System; Labile

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States