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NCT05435547PHASE4Recruiting

Preoperative Corticosteroids in Autoimmune Thyroid Disease

Indiana University

Start Date

6/16/2023

Completion Date

12/30/2026

Summary

This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.

Eligibility Criteria

Age Range: 18 years to No maximum

* Inclusion Criteria: ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease. * Exclusion Criteria: * Pediatric patients \< 18 * Prior treatment with RAI * Prior neck surgeries * Known diagnosis of thyroid cancer * Diabetic patients on medications * A history of adverse reactions to corticosteroids. * Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.

Interventions

DRUG

Dexamethasone

DRUG

Placebo

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Conditions

Graves DiseaseHashimoto Disease

Locations

IU Health North Hospital

Indianapolis, Indiana 46032

United States

IU Health Methodist Hospital

Indianapolis, Indiana 46202

United States

IU Health University Hospital

Indianapolis, Indiana 46202

United States