NCT05435547PHASE4Recruiting
Preoperative Corticosteroids in Autoimmune Thyroid Disease
Indiana University
Start Date
6/16/2023
Completion Date
12/30/2026
Summary
This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.
Eligibility Criteria
Age Range: 18 years to No maximum
* Inclusion Criteria:
■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease.
* Exclusion Criteria:
* Pediatric patients \< 18
* Prior treatment with RAI
* Prior neck surgeries
* Known diagnosis of thyroid cancer
* Diabetic patients on medications
* A history of adverse reactions to corticosteroids.
* Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.
Interventions
DRUG
Dexamethasone
DRUG
Placebo
Conditions
Graves DiseaseHashimoto Disease
Locations
IU Health North Hospital
Indianapolis, Indiana 46032
United States
IU Health Methodist Hospital
Indianapolis, Indiana 46202
United States
IU Health University Hospital
Indianapolis, Indiana 46202
United States