A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Start Date
11/11/2022
Completion Date
8/18/2028
Summary
The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4).
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Amivantamab
Lazertinib
Carboplatin
Pemetrexed
Direct Oral Anticoagulant (DOAC)
Low Molecular Weight Heparin (LMWH)
Conditions
Locations
University of California at San Diego
La Jolla, California 92093
United States
University of California Irvine
Orange, California 92868
United States
Stanford Cancer Institute
Stanford, California 94305
United States
Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital
Washington D.C., District of Columbia 20016
United States
Baptist Lynn Cancer Institute
Boca Raton, Florida 33486
United States
Mount Sinai Medical Center
Miami Beach, Florida 33140
United States
AdventHealth
Orlando, Florida 32804
United States
H. Lee Moffitt Cancer & Research Institute
Tampa, Florida 33612
United States
University of Kansas Cancer Center
Westwood, Kansas 66205
United States
Sidney Kimmel Cancer Center - Bayview Campus
Baltimore, Maryland 21224
United States
Boston Medical Center
Boston, Massachusetts 02118
United States
Washington University School Of Medicine
St Louis, Missouri 63110
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08901
United States
Hematology-Oncology Associates of CNY
East Syracuse, New York 13057
United States
Novant Health 1
Charlotte, North Carolina 28204
United States
Novant Health
Winston-Salem, North Carolina 27106
United States
Cleveland Clinic 1
Cleveland, Ohio 44111
United States
Cleveland Clinic
Cleveland, Ohio 44195
United States
Cleveland Clinic 2
Mayfield Heights, Ohio 44124
United States
Cleveland Clinic 3
Warrensville Heights, Ohio 44122
United States
The Huntsman Cancer Institute
Salt Lake City, Utah 84112
United States
Virginia Cancer Specialists
Fairfax, Virginia 22031
United States
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Virginia Mason Medical Center
Seattle, Washington 98101
United States
Swedish Cancer Institute
Seattle, Washington 98104
United States
Fundacao Pio XII
Barretos, 14784-400
Brazil
PERSONAL Oncologia de Precisao e Personalizada
Belo Horizonte, 30130 090
Brazil
Instituto do Cancer de Londrina Hospital do Cancer de Londrina
Londrina, 86015
Brazil
Associacao Hospitalar Moinhos de Vento
Porto Alegre, 90035-001
Brazil
Instituto D Or de Pesquisa e Ensino IDOR
Rio de Janeiro, 22281 100
Brazil
Instituto D Or de Pesquisa e Ensino IDOR 1
Salvador, 41253-190
Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, 01327 001
Brazil
Impar Servicos Hospitalares SA Hospital Nove de Julho
São Paulo, 01409-001
Brazil
Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, 01509 900
Brazil
Affiliated Hospital of Hebei University
Baoding, 071051
China
Jilin cancer hospital
Changchun, 130000
China
Sichuan Cancer Hospital
Chengdu, 610041
China
West China Hospital Sichuan University
Chengdu, 610047
China
The First Affiliated Hospital of PLA Army Medical University
Chongqing, 400038
China
The First Affiliated Hospital Sun Yat sen University
Guangzhou, 510060
China
The First Affiliated Hospital Zhejiang University College of Medicine
Hangzhou, 310003
China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, 310016
China
Harbin medical university cancer hospital
Harbin, 150000
China
Huizhou Municipal Central Hospital
Huizhou, 516001
China
Liuzhou people's Hospital
Liuzhou, 545006
China
Fudan University Shanghai Cancer Center
Shanghai, 200032
China
Tianjin Medical University General Hospital
Tianjin, 300052
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
China
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan, 430022
China
Hospital of Jiangnan University
Wuxi, 214122
China
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061
China
Yantai Yuhuangding Hospital
Yantai, 264000
China
Centre Francois Baclesse
Caen, 14076
France
Centre Georges-François Leclerc
Dijon, 21079
France
Institut de Cancérologie du Gard
Nîmes, 30029
France
Institut Curie
Paris, 75248
France
Institut de cancerologie de l'ouest
Saint-Herblain, 44805
France
Gustave Roussy
Villejuif, 94800
France
Evangelische Lungenklinik Berlin
Berlin, 13125
Germany
Universitaetsklinikum Koeln
Cologne, 50937
Germany
LungenClinic Grosshansdorf GmbH
Grosshandorf, 22927
Germany
Lungenfachklinik Immenhausen
Immenhausen, 34376
Germany
Klinikum Würzburg Mitte gGmbH Standort Missioklinik
Würzburg, 97074
Germany
Rambam Medical Center
Haifa, 3109601
Israel
Shaare Zedek Medical Center
Jerusalem, 9103102
Israel
Meir Medical Center
Kfar Saba, 44281
Israel
Rabin Medical Center
Petah Tikva, 4941492
Israel
Sheba Medical Center
Ramat Gan, 52621
Israel
Policlinico Hospital San Martino- IRCCS for Oncology
Genova, 16132
Italy
Ospedale San Raffaele
Milan, 20132
Italy
ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162
Italy
Azienda Ospedaliera San Gerardo
Monza, 20090
Italy
Azienda Ospedaliera Specialistica dei Colli
Naples, 80131
Italy
National Hospital Organization Himeji Medical Center
Himeji, 670-8520
Japan
Saiseikai Matsusaka Municipal Hospital
Matsusaka, 515 8544
Japan
Niigata Cancer Center Hospital
Niigata, 951-8566
Japan
Shizuoka Cancer Center
Shizuoka, 411 8777
Japan
The Cancer Institute Hospital of JFCR
Tokyo, 135 8550
Japan
Wakayama Medical University Hospital
Wakayama, 641 8510
Japan
University Malaya Medical Centre
Kuala Lumpur, 59100
Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, 25100
Malaysia
Hospital Umum Sarawak
Kuching, 93586
Malaysia
Beacon Hospital Sdn Bhd
Petaling Jaya, 46050
Malaysia
National Cancer Center
Goyang-si, 10408
South Korea
Seoul National University Bundang Hospital
Seongnam-si, 13620
South Korea
Seoul National University Hospital
Seoul, 03080
South Korea
Severance Hospital Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Hosp Univ A Coruna
A Coruña, 15006
Spain
General University Hospital of Alicantet
Alicante, 03010
Spain
Hosp. Del Mar
Barcelona, 08003
Spain
Hosp. de La Santa Creu I Sant Pau
Barcelona, 08025
Spain
Hosp Univ Vall D Hebron
Barcelona, 08035
Spain
Inst. Cat. Doncologia-H Duran I Reynals
Barcelona, 8908
Spain
Hosp. Gral. Univ. Gregorio Maranon
Madrid, 28007
Spain
Hosp. Univ. Ramon Y Cajal
Madrid, 28034
Spain
Hosp. Univ. 12 de Octubre
Madrid, 28041
Spain
Hosp. Univ. La Paz
Madrid, 28046
Spain
Hosp Regional Univ de Malaga
Málaga, 29010
Spain
Hosp. Virgen Macarena
Seville, 41009
Spain
Hosp. Clinico Univ. de Valencia
Valencia, 46010
Spain
Hosp. Gral. Univ. Valencia
Valencia, 46014
Spain
Cheltenham General Hospital
Cheltenham, GL53 7AN
United Kingdom
Torbay Hospital-Devon
Devon, TQ2 7AA
United Kingdom
Edinburgh Cancer Centre Western General
Edinburgh, EH4 2XU
United Kingdom
Leicester Royal Infirmary
Leicester, LE1 5WW
United Kingdom
University College London Hospitals
London, NW1 2PG
United Kingdom
Nottingham City Hospital
Nottingham, NG5 1PB
United Kingdom
Queen Alexandra Hospital
Portsmouth, PO6 3LY
United Kingdom