NCT05612789NARecruiting

Improve Outcomes for Older Allogeneic Transplant Recipients

Abramson Cancer Center at Penn Medicine

Start Date

2/15/2023

Completion Date

6/1/2031

Summary

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.

Eligibility Criteria

Age Range: 60 years to No maximum

Inclusion Criteria: Cohort A (Prehab) 1. Age 60 years or older. 2. Planned allogeneic HCT in the next 1-6 months. 3. Hematological malignancy as the indication for HCT. 4. Pre-frail or frail by Fried frailty phenotype. Cohort B (Rehab) 1. Age 60 years or older. 2. Planned allogeneic HCT or HCT within the last 30 days. 3. Hematological malignancy as the indication for HCT. Exclusion Criteria: Cohorts A and B 1\. Comorbid disability or illness that prevents safe exercise.

Interventions

BEHAVIORAL

Exercise Program (Cohort A Prehab)

BEHAVIORAL

Exercise Program (Cohort B Rehab)

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Conditions

Allogeneic Transplantation

Locations

Penn Medicine

Philadelphia, Pennsylvania 19104

United States