NCT05839652PHASE4Recruiting
Treatment of Orthostatic Hypotension in SCI
James J. Peters Veterans Affairs Medical Center
Start Date
7/1/2023
Completion Date
6/30/2026
Summary
The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.
Eligibility Criteria
Age Range: 18 years to 60 years
Inclusion Criteria:
* traumatic spinal cord injury
* at least 12 months post injury
* injury level of C1-T6
* AIS A, B or C
* non-ambulatory
* non-ventilator
Exclusion Criteria:
* Active psychiatric disorder
* Stroke or cerebrovascular disease
* Alzheimer's Disease or dementia
* Unmanaged cardiac arrhythmias
* Concurrent systemic, hepatic, or renal disease
* Suspected or diagnosed malignancy
* Neurological disease other than SCI
* Self-reported history of three or more symptomatic episodes of AD per day
Interventions
DRUG
Midodrine Hydrochloride
Conditions
Hypotension
Locations
Kessler Foundation
West Orange, New Jersey 07052
United States
James J Peters VA Medical Center
The Bronx, New York 10468
United States