NCT05865054RecruitingAccepts Healthy Volunteers

Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)

University of Pennsylvania

Start Date

7/29/2020

Completion Date

7/1/2033

Summary

The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).

Detailed Description

After signing the consent form, participants will complete an MRI scan within 2 weeks of enrollment and fill out questionnaires related to their disease. Follow up visits and MRI scans may occur at 6-months after the initial MRI scan or at the time of relapse.

Eligibility Criteria

Age Range: 50 years to No maximum

Inclusion Criteria: * Age 50 years or older * First presentation of suspected GCA * New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA * Elevated CRP greater than 1.0 mg/dl * Plan to undergo temporal artery biopsy or ultrasound for diagnosis Exclusion Criteria: * Contra-indication to receiving MRI including: Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing * Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)

Interventions

DIAGNOSTIC_TEST

Magnetic Resonance Imaging (MRI)

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Giant Cell Arteritis

Locations

Mayo Building and Gonda Building

Rochester, Minnesota 55905

United States

3400 Civic Center Blvd

Philadelphia, Pennsylvania 19104

United States

St. Joseph's Healthcare Hamilton

Hamilton, Ontario L8G 5E4

Canada

University Hospital Wuerzburg

Würzburg, Würzburg 97080

Germany