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NCT05972265NARecruitingAccepts Healthy Volunteers

Childhood Trauma, Exercise, and Cognition

University of Texas at Austin

Start Date

11/27/2023

Completion Date

6/4/2027

Summary

This study aims to identify and compare the effects of acute and chronic exercise interventions on cognition in middle-aged adults with cognitive complaints and a history of abuse or neglect in childhood. Each participant will be enrolled in the study for up to 78 days, in five parts following verification that the participant meets criteria to be included in the study: 1) initial assessment; 2) first acute exercise condition in lab, symptom measures, and neuropsychological testing; 3) second acute exercise condition in lab, symptom measures, and neuropsychological testing; and 4) 9-week exercise intervention or activity as usual outside of lab, with interview, symptom measures, and neuropsychological testing at three-week intervals.

Eligibility Criteria

Age Range: 40 years to 60 years

Inclusion Criteria: * between 40 and 60 years of age * history of child abuse or neglect * have a complaint about memory, attention, or executive function * native or fluent English speaker * normal or corrected to normal vision and hearing * medically healthy Exclusion Criteria: * Score indicating a history of moderate-intensity activity, hard-intensity activity, or very-hard intensity activity on the Stanford Brief Activity Survey * current excessive alcohol or other substance use * eating disorder, bipolar disorder, schizophrenia spectrum disorders, or those judged to be an immediate suicide risk based on having an active plan with intent * autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), or other neurodevelopmental disorder * neurocognitive disorder, or illnesses or history of neurological events known to cause neurocognitive disorders (e.g., traumatic brain injury, status epilepticus, stroke) * reported chest pain or dizziness during exercise; any endorsed and not controlled medical condition that could make exercise contraindicated, including hypertension; heart disease; heart failure; hear rhythm disorders; heart valve disease; metabolic conditions; chronic obstructive pulmonary disease; pulmonary hypertension; cystic fibrosis; asthma; and bone, joint, or soft tissue problems * pregnancy, major medical disorders such as cancer, or any other condition believed to put a participant at risk

Interventions

BEHAVIORAL

Moderate Intensity Exercise (one day)

BEHAVIORAL

Placebo - Light Intensity Exercise (one day)

BEHAVIORAL

Moderate Intensity Exercise (9 wks)

OTHER

Day 1 Assessments

OTHER

Symptom Measures and Neuropsychological Tests

OTHER

Day 36 Assessments

OTHER

Day 57 Assessments

OTHER

Day 78 Assessments

Interested in This Trial?

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Conditions

Adverse Childhood Experiences

Locations

University of Texas at Austin

Austin, Texas 78712

United States