NCT06039566PHASE3Recruiting

NAC vs Placebo on Opioid Use for Hysterectomy

Medical University of South Carolina

Start Date

11/30/2023

Completion Date

12/9/2026

Summary

This study will enroll females who are ages 18 and older undergoing a laparoscopic or robotic, partial or full hysterectomy. Participants will be randomized to receive IV n-acetylcysteine or placebo during the first 60 minutes of their procedure. At various time points after the procedure patients will be asked to report their pain scores, and any pain medication taken.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion * Undergoing elective laparoscopic or robotic, full, or partial hysterectomy procedure * 18 years of age and older Exclusion * Less than 40kg in weight * Unable to provide written, informed consent * History of an adverse or anaphylactoid reaction to acetylcysteine * Active asthma, wheezing, or using inhaled bronchodilators * Non-English speaking * Insulin dependent diabetes if D5W is required * Blood clotting disorders

Interventions

DRUG

IV N-acetylcysteine

DRUG

IV Placebo

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Conditions

Hysterectomy

Locations

Medical University of South Carolina

Charleston, South Carolina 29425

United States