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NCT06087458PHASE1, PHASE2Recruiting

Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Perceive Biotherapeutics, Inc.

Start Date

6/21/2023

Completion Date

3/1/2028

Summary

The Phase 1 safety study of VOY-101 comprises of escalating dose Cohorts, followed by a Phase 2a.

Detailed Description

This is a prospective, open-label, multi-center Phase 1/2a study to evaluate the safety of a single, unilateral intravitreal (IVT) injection of escalating dose levels of VOY-101 therapy in subjects with advanced non-neovascular age-related macular degeneration (AMD).

Eligibility Criteria

Age Range: 60 years to No maximum

Inclusion Criteria: * Are ≥60 years of age at the time of consent. * Are willing and able to understand and provide written informed consent. * Are willing and able to return for scheduled treatment and follow-up examinations. * Are able to undergo ETDRS BCDVA testing and ophthalmic imaging. * Well-demarcated GA secondary to AMD in the absence of MNV and in the absence of history of MNV for both eyes. * Absence of signs of non-exudative MNV. * Additional Ocular Inclusion Criteria for both eyes. * Meet certain genotype criteria for risk of AMD. Exclusion Criteria: * Are women of childbearing potential (WOCBP) and are pregnant or unwilling to use and document use of effective contraception for the duration of the study. * Additional Systemic, Ocular, and Genetic Exclusion Criteria.

Interventions

BIOLOGICAL

VOY-101

Interested in This Trial?

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Conditions

Age-Related Macular DegenerationGeographic AtrophyNon-neovascular AMD

Locations

Retina Macula Institute of AZ

Scottsdale, Arizona 85255

United States

The Retina Partners

Encino, California 91436

United States

Retinal Consultants Medical Group

Sacramento, California 95825

United States

Retina Consultants San Diego

San Diego, California 92064

United States

Star Retina

Burleson, Texas 76028

United States

Retina Center of Texas

Southlake, Texas 76092

United States

University of Utah John A. Moran Eye Center

Salt Lake City, Utah 84132

United States

Sydney Retina Clinic and Day Surgery

Sydney, New South Wales 2000

Australia

Cerulea Clinical Trials

East Melbourne, Victoria 3002

Australia

Rambam Medical Center

Haifa,

Israel

Tel-Aviv Sourasky Medical Center, Ophthalmology Division

Tel Aviv, 64239

Israel