NCT06223607Recruiting

Dual Antiplatelet Therapy (DAPT) in Patients With Baseline Thrombocytopenia

Methodist Health System

Start Date

8/22/2022

Completion Date

12/22/2027

Summary

The use of clopidogrel as part of DAPT will be associated with lower bleeding rates compared to ticagrelor in patients with chronic thrombocytopenia requiring Percutaneous intervention (PCI )with Drug Eluting Stent (DES) or Bare Metal Stint(BMS).

Detailed Description

Patients with thrombocytopenia are at an increased risk of both bleeding and ischemic events following PCI; however, there is a paucity of data on how to optimally manage these risks. Data indicates that ticagrelor is associated with reduced ischemic outcomes with an accompanying increased risk of bleed in the broader population. This study will assess P2Y12 agent selection in patients with chronic thrombocytopenia to determine if one better balances risks of ischemic and bleeding events following coronary intervention

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * ≥ 18 years * PCI with either DES or BMS during study time period (April 1, 2018 through July 1 2021) * Thrombocytopenia defined as platelet count \<100 x103 /µL on at least one occasion prior to PCI * At least one dose of DAPT post-PCI with aspirin and either clopidogrel or ticagrelor Exclusion Criteria: * Death within 48 hours post-PCI * DAPT prior to cardiac catheterization

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Conditions

Baseline Thrombocytopenia

Locations

Methodist Dallas Medical Center

Dallas, Texas 75203

United States