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NCT06238622PHASE3Recruiting

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

Boehringer Ingelheim

Start Date

5/6/2024

Completion Date

5/5/2027

Summary

This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550. The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need to go to the hospital, or die. Every participant takes nerandomilast as tablets for up to 1 year and 10 months. The participants may also continue their regular treatment for pulmonary fibrosis during the study. Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. Participants also regularly do lung function tests.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Patients who completed treatment in the parent trials (1305-0014, 1305-0023, or 1305-0035) without prematurely discontinuing treatment permanently according to protocol (i.e. completed treatment with or without temporary treatment interruption) 2. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial 3. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. WOCBP taking oral contraceptives (OCs) also have to ensure the use of one barrier method during sexual intercourse with their partner, e.g., condom to account for the risk of potentially reduced efficacy of the OCs in the event of severe vomiting and diarrhoea. For France, fertile males must be ready and able to use acceptable methods of birth control Exclusion Criteria: 1. Any disease that may put the patient at risk when participating in this trial at investigator's discretion. 2. Patient exhibits suicidality, in the clinical judgment of the investigator or according to the following criteria at Visit 1: * any suicidal behaviour (i.e. actual attempt, interrupted attempt, aborted attempt, or preparatory acts or behaviour) * any suicidal ideation of type 4 or 5 in the Columbia-Suicide Severity Rating Scale (C-SSRS) (i.e. active suicidal thought with intent but without specific plan, or active suicidal thought with plan and intent) 3. Patients with clinically relevant severe depression at investigator's discretion or a Hospital Anxiety and Depression Scale (HADS) subscore \>14 at Visit 1. 4. An occurrence of malignant neoplasm other than appropriately treated basal cell carcinoma or in situ squamous cell carcinoma of the skin or in situ carcinoma of uterine cervix at Visit 1. 5. Patient will undergo lung transplantation, with an assigned date of surgery. 6. Patients with a Body Mass index (BMI) \<18.5 kg/m² that experienced an additional, unexplained and clinically significant (\>10%) weight loss during the parent trial 7. At Visit 1, patients with ongoing Adverse Event of Special Interest (AESI), except for latent tuberculosis (suspected vasculitis, Drug Induced Liver Injury (DILI), severe infections) that led to temporary treatment interruption in the parent trial 8. Patients who must or wish to take restricted medications or any drug considered likely to interfere with the safe conduct of the trial. Further exclusion criteria apply.

Interventions

DRUG

Nerandomilast

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Conditions

Idiopathic Pulmonary FibrosisProgressive Pulmonary Fibrosis

Locations

University of Alabama at Birmingham

Birmingham, Alabama 35233

United States

University of Arizona

Tucson, Arizona 85724

United States

University of Southern California

Los Angeles, California 90033

United States

Cedars-Sinai Medical Center

Los Angeles, California 90048

United States

University of California Los Angeles

Los Angeles, California 90095

United States

University of California Davis

Sacramento, California 95817

United States

National Jewish Health

Denver, Colorado 80206

United States

Yale University School of Medicine

New Haven, Connecticut 06510

United States

Christiana Hospital

Newark, Delaware 19713

United States

Georgetown University

Washington D.C., District of Columbia 20007

United States

St. Francis Medical Institute

Clearwater, Florida 33765

United States

University of Florida

Gainesville, Florida 32610

United States

Clinical Research Specialists LLC - Kissimmee

Kissimmee, Florida 34746

United States

Advanced Pulmonary Research Institute

Loxahatchee Groves, Florida 33470

United States

Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead

Atlanta, Georgia 30309

United States

The Emory Clinic

Atlanta, Georgia 30322

United States

Northshore University Health System

Evanston, Illinois 60201

United States

University of Kansas Medical Center

Kansas City, Kansas 66160

United States

Tulane Medical Center

New Orleans, Louisiana 70112

United States

Johns Hopkins Hospital

Baltimore, Maryland 21224

United States

Massachusetts General Hospital

Boston, Massachusetts 02114

United States

Brigham and Women's Hospital

Boston, Massachusetts 02115

United States

St. Elizabeth's Medical Center

Boston, Massachusetts 02135

United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts 02215

United States

University of Michigan

Ann Arbor, Michigan 48109

United States

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan 48073

United States

University of Minnesota

Minneapolis, Minnesota 55455

United States

Mayo Clinic, Rochester

Rochester, Minnesota 55905

United States

The Lung Research Center, LLC

Chesterfield, Missouri 63017

United States

Creighton University

Omaha, Nebraska 68124

United States

University of Nebraska Medical Center

Omaha, Nebraska 68198

United States

Renown Regional Medical Center

Reno, Nevada 89502

United States

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire 03756

United States

Northern Westchester Hospital

Mount Kisco, New York 10549

United States

Columbia University Medical Center-New York Presbyterian Hospital

New York, New York 10032

United States

NewYork-Presbyterian/Weill Cornell Medical Center

New York, New York 10065

United States

Duke University Medical Center

Durham, North Carolina 27710

United States

Southeastern Research Center-Winston Salem-69289

Winston-Salem, North Carolina 27103

United States

University of Cincinnati

Cincinnati, Ohio 45267

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

The Ohio State University Wexner Medical Center

Columbus, Ohio 43210

United States

The Oregon Clinic

Portland, Oregon 97220

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Temple University Hospital

Philadelphia, Pennsylvania 19140

United States

Allegheny General Hospital

Pittsburgh, Pennsylvania 15212

United States

Infinity Medical Research, Inc.

East Providence, Rhode Island 02914

United States

Lowcountry Lung and Critical Care

Charleston, South Carolina 29406

United States

Clinical Trials Center of Middle Tennessee, LLC

Franklin, Tennessee 37067

United States

Vanderbilt University Medical Center

Nashville, Tennessee 37204

United States

Baylor University Medical Center

Dallas, Texas 75246

United States

UT Health San Antonio

San Antonio, Texas 78229

United States

Renovatio Clinical-The Woodlands-69551

The Woodlands, Texas 77380

United States

Intermountain Medical Center-Murray-69497

Murray, Utah 84107

United States

University of Utah Health Sciences Center

Salt Lake City, Utah 84108

United States

University of Vermont

Burlington, Vermont 05401

United States

Inova Fairfax Hospital

Falls Church, Virginia 22042

United States

Virginia Mason Medical Center

Seattle, Washington 98101

United States

University of Wisconsin

Madison, Wisconsin 53792

United States

Centro de Investigaciones Metabolicas (CINME)

C.a.b.a, 1056

Argentina

CEDIC - Centro de Investigacion Clinica

CABA, C1060ABN

Argentina

Hospital Italiano de Buenos Aires

CABA, C1199ABD

Argentina

Consultorios Médicos del Buen Ayre

Capital Federal, 1425

Argentina

CEMER-Centro Medico De Enfermedades Respiratorias

Florida, B1602DQD

Argentina

Instituto Ave Pulmo - Fundacion Enfisema

Mar del Plata, 7600

Argentina

INSARES

Mendoza, M5500CCG

Argentina

Centro Respiratorio de Quilmes

Quilmes, B1878FNR

Argentina

Instituto Médico de la Fundación Estudios Clínicos

Rosario, S2000DEJ

Argentina

Canberra Hospital

Garran, Australian Capital Territory 2605

Australia

Royal Prince Alfred Hospital

Camperdown, New South Wales 2050

Australia

Westmead Hospital

Westmead, New South Wales 2145

Australia

Lung Research Queensland

Chermside, Queensland 4032

Australia

The Prince Charles Hospital

Chermside, Queensland 4032

Australia

Royal Adelaide Hospital

Adelaide, South Australia 5000

Australia

Austin Hospital

Heidelberg, Victoria 3084

Australia

The Alfred Hospital

Melbourne, Victoria 3004

Australia

Fiona Stanley Hospital

Murdoch, Western Australia 6150

Australia

Trialswest

Spearwood, Western Australia 6163

Australia

Macquarie University

Macquarie Park, 2109

Australia

Krems University Hospital

Krems, 3500

Austria

LKH Salzburg University Hospital

Salzburg, 5020

Austria

AKH - Medical University of Vienna

Vienna, 1090

Austria

Standort Penzing der Klinik Ottakring

Vienna, 1140

Austria

Clinic Floridsdorf

Vienna, 1210

Austria

Klinikum Wels - Grieskirchen GmbH

Wels, 4600

Austria

Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim

Antwerp, 2020

Belgium

Hopital Erasme

Brussels, 1070

Belgium

Cliniques Universitaires Saint-Luc

Brussels, 1200

Belgium

Universitair Ziekenhuis Gent

Ghent, 9000

Belgium

UZ Leuven

Leuven, 3000

Belgium

Centre Hospitalier Universitaire de Liège

Liège, 4000

Belgium

Yvoir - UNIV UCL de Mont-Godinne

Yvoir, 5530

Belgium

Serviços Medicos Respirar Sul Fluminense

Barra Mansa, 27323240

Brazil

Hospital das Clinicas da Universidade Federal de Minas Gerais (HC-UFMG)

Belo Horizonte,Minas Gerais, 31270901

Brazil

SAPIENS - Instituto de Estudos e Pesquisa Clínica

Curitiba, 80810-000

Brazil

CLARE - Clinica de Pneumologia

Goiânia, 74110-030

Brazil

Irmandade Santa Casa de Misericordia de Porto Alegre

Porto Alegre, 90020-090

Brazil

Hospital Nossa Senhora da Conceição

Porto Alegre - RS, 91350-250

Brazil

CEMEC - Centro Multidisciplinar de Estudos Clínicos

São Bernardo do Campo, 09715-090

Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, 01327-001

Brazil

Hospital das Clínicas da Faculdade de Medicina da USP

São Paulo, 05403-000

Brazil

University of Alberta Hospital (University of Alberta)

Edmonton, Alberta T6G 1Z1

Canada

Kelowna Respirology & Allergy Research

Kelowna, British Columbia V1Y 3H5

Canada

St. Paul's Hospital (Vancouver)

Vancouver, British Columbia V1Y 1S1

Canada

Vancouver General Hospital

Vancouver, British Columbia V5Z 1M9

Canada

Dr. Georges-L.-Dumont University Hospital Centre

Moncton, New Brunswick E1C 2Z3

Canada

QEII Health Sciences Centre

Halifax, Nova Scotia B3H 3A7

Canada

St. Joseph's Healthcare Hamilton

Hamilton, Ontario L8N 1Y2

Canada

Dr. Syed Anees Medicine Professional Corporation

Windsor, Ontario N8X 1T3

Canada

Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec H2X 0C1

Canada

McGill University Health Centre (MUHC)

Montreal, Quebec H4A 3J1

Canada

CIC Mauricie (Trois Rivieres)

Trois-Rivières, Quebec G8T 7A1

Canada

Royal University Hospital (Saskatoon)

Saskatoon, Saskatchewan S7N 0W8

Canada

Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)

Québec, G1V 4G5

Canada

Instituto Nacional del Tórax

Providencia, Santiago de Chile, 7500000

Chile

Centro de Investigación del Maule

Talca, 3465586

Chile

Beijing Chao-Yang Hospital

Beijing, 100020

China

China-Japan Friendship Hospital

Beijing, 100029

China

Peking Union Medical College Hospital

Beijing, 100730

China

The Second Xiangya Hospital Of Central South University

Changsha, 410011

China

West China Hospital, Sichuan University

Chengdu, 610041

China

People's Hospital of Sichuan Province

Chengdu, 610072

China

First Affiliated Hospital of Guangzhou Medical University

Guangzhou, 510120

China

NanFang Hosptial

Guangzhou, 510515

China

Hangzhou First People's Hospital

Hangzhou, 310006

China

The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, 310009

China

Zhejiang Hospital

Hangzhou, 310013

China

Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

Hangzhou, 310016

China

Anhui Provincial Hospital

Hefei, 230001

China

The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, 010000

China

The First hospital of Jiaxing

Jiaxing, 314000

China

Jinhua Municipal Central Hospital

Jinhua, 321000

China

Nanjing Drum Tower Hospital

Nanjing, 210008

China

Ningbo Medical Center Lihuili Hospital

Ningbo, 315000

China

The First Affiliated Hospital of Ningbo University

Ningbo, 315010

China

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, 200025

China

Shanghai Chest Hospital

Shanghai, 200030

China

Zhongshan Hospital Affiliated to Fudan University

Shanghai, 200032

China

Huadong Hospital affiliated to Fudan University

Shanghai, 200040

China

China Shenyang Chest Hospital

Shenyang, 110000

China

Shenzhen People's Hospital

Shenzhen, 518020

China

The University of Hong Kong-Shenzhen Hospital

Shenzhen, 518053

China

The First Affiliated Hospital of Soochow University

Suzhou, 215006

China

Tianjin Medical University General Hospital

Tianjin, 30052

China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, 325000

China

Wuhan Union Hospital

Wuhan, 430022

China

Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T

Wuhan, 430030

China

Renmin Hospital of Wuhan University

Wuhan, 430060

China

Wuxi People's Hospital

Wuxi, 214043

China

Second Affiliated Hospital of Xi'an JiaoTong University

Xi'an, 710004

China

Affiliated Hospital, Xuzhou Medical college

Xuzhou, 221009

China

Yichang Central People's Hospital

Yichang, 443000

China

General Hospital of Ningxia Medical University

Yinchuan, 750004

China

University hospital center Zagreb

Zagreb, 10000

Croatia

University Hospital Dubrava

Zagreb, 10000

Croatia

Solmed Polyclinic

Zagreb, 1000

Croatia

University Thomayer´s Hospital

Prague, 140 59

Czechia

Gentofte Hospital

Hellerup, 2900

Denmark

Odense University Hospital

Odense C, 5000

Denmark

North Estonia Medical Centre Foundation, Tallinn

Tallinn, 13419

Estonia

HYKS Keuhkosairauksien tutkimusyksikkö

Helsinki, 00029

Finland

Oulun yliopistollinen keskussairaala

Oulu, 90220

Finland

Tampere University Hospital

Tampere, 33520

Finland

TYKS

Turku, 20520

Finland

HOP d'Angers

Angers, 49933

France

HOP Avicenne

Bobigny, 93000

France

HOP de la Cavale Blanche

Brest, 29200

France

Hôpital Louis Pradel

Bron, 69677

France

HOP CHU Caen

Caen, 14033

France

HOP François Mitterrand

Dijon, 21000

France

HOP Michallon

La Tronche, 38700

France

HOP Bicêtre

Le Kremlin-Bicêtre, 94275

France

INS Coeur Poumon

Lille, 59037

France

HOP Nord

Marseille, 13915

France

HOP Nord Laennec

Nantes, 44093

France

Hopital Pasteur

Nice, 06001

France

HOP Paris Saint-Joseph

Paris, 75014

France

HOP Européen G. Pompidou

Paris, 75015

France

HOP Bichat

Paris, 75877

France

HOP Haut-Lévêque

Pessac, 33604

France

HOP Robert Debré

Reims, 51100

France

HOP Pontchaillou

Rennes, 35033

France

Hôpital Charles Nicolle

Rouen, 76031

France

HOP Foch

Suresnes, 92151

France

Hôpital Larrey - CHU de Toulouse

Toulouse, 31059

France

National Center for Tuberculosis and Lung Diseases, Tbilisi

Tbilisi, 0101

Georgia

LLC Diacor

Tbilisi, 0159

Georgia

LTD The First Medical Center

Tbilisi, 0180

Georgia

Velocity Clinical Research Germany GmbH, Ahrensburg

Ahrensburg, 22926

Germany

CIMS Studienzentrum Bamberg GmbH

Bamberg, 96049

Germany

Vivantes Netzwerk für Gesundheit GmbH

Berlin, 12351

Germany

Universitätsklinikum Bonn AöR

Bonn, 53127

Germany

Fachkrankenhaus Coswig GmbH

Coswig, 01640

Germany

Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH

Essen, 45239

Germany

Universitätsklinikum Hamburg, Eppendorf

Hamburg, 20246

Germany

Klinikum Region Hannover GmbH

Hanover, 30459

Germany

Medizinische Hochschule Hannover

Hanover, 30625

Germany

Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg

Heidelberg, 69126

Germany

Lungenklinik Hemer

Hemer, 58675

Germany

Lungenfachklinik Immenhausen

Immenhausen, 34376

Germany

Klinikum Konstanz

Konstanz, 78464

Germany

Klinikum der Universität München AÖR

München, 81377

Germany

Klinikum Nürnberg

Nuremberg, 90419

Germany

Krankenhaus Bethanien gGmbH

Solingen, 42699

Germany

Helios Hanseklinikum Stralsund

Stralsund, 18435

Germany

Robert Bosch Gesellschaft für medizinische Forschung mbH

Stuttgart, 70376

Germany

Universitätsklinikum Tübingen

Tübingen, 72076

Germany

Hospital of Heraklion (PAGNI)

Heraklion, 71110

Greece

Univ. Gen. Hosp. of Ioannina

Ioannina, 45 500

Greece

Univ. Gen. Hosp. of Patras

Pátrai, 26504

Greece

General Hospital of Thessaloniki "Hippokrateio"

Thessaloniki, 546 42

Greece

Koranyi National Institute For Pulmonolgy

Budapest, 1121

Hungary

University of Debrecen Clinical Centre

Debrecen, 4032

Hungary

Bhatia Hospital

Mumbai, 400007

India

P.D. Hinduja National Hospital

Mumbai, 400067

India

Connolly Hospital Blanchardstown

Dublin, D15 X40D

Ireland

Shamir Medical Center (Assaf Harofeh)

Beer Yaakov, 7033001

Israel

Lady Davis Carmel Medical Center

Haifa, 3436212

Israel

Shaare Zedek Medical Center

Jerusalem, 9103102

Israel

Sourasky Medical Center

Tel Aviv, 6093246

Israel

ASST degli Spedali Civili di Brescia

Brescia, 25123

Italy

A.O.U. Policlinico Vittorio Emanuele

Catania, 95124

Italy

A. O. Universitaria Careggi

Florence, 50137

Italy

Ospedale Colonnello D Avanzo

Foggia, 71100

Italy

Ospedale G.B. Morgagni

Forlì, 47121

Italy

Ospedale San Paolo-MILANO-18793

Milan, 20100

Italy

Ospedale Classificato San Giuseppe

Milan, 20123

Italy

Azienda Ospedaliero-Universitaria di Modena

Modena, 41100

Italy

A.O. San Gerardo di Monza

Monza, 20052

Italy

Azienda Ospedaliera Universitaria di Padova

Padova, 35128

Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168

Italy

A.O.U. Senese

Siena, 53100

Italy

Ospedali Riuniti di Ancona

Torrette Di Ancona (Ancona), 60126

Italy

Tosei General Hospital

Aichi, Seto, 489-8642

Japan

Chiba University Hospital

Chiba, Chiba, 260-8677

Japan

University of Fukui Hospital

Fukui, Yoshida-gun, 910-1193

Japan

National Hospital Organization Kyushu Medical Center

Fukuoka, Fukuoka, 810-8563

Japan

Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582

Japan

Aso Co.,Ltd Iizuka Hospital

Fukuoka, Iizuka, 820-8505

Japan

Hospital of the University of Occupational and Environmental Health

Fukuoka, Kitakyushu, 807-8556

Japan

Kurume University Hospital

Fukuoka, Kurume, 830-0011

Japan

Fukushima Medical University Hospital

Fukushima, Fukushima, 960-1295

Japan

Tsuboi Hospital

Fukushima, Koriyama, 963-0197

Japan

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, 734-8530

Japan

Sapporo Medical University Hospital

Hokkaido, Sapporo, 060-8543

Japan

Hokkaido University Hospital

Hokkaido, Sapporo, 060-8648

Japan

National Hospital Organization Himeji Medical Center

Hyogo, Himeji, 670-8520

Japan

Kobe City Medical Center General Hospital

Hyogo, Kobe, 650-0047

Japan

Kobe City Hospital Organization Kobe City Medical Center West Hospital

Hyogo, Kobe, 653-0013

Japan

Kagawa University Hospital

Kagawa, Kita-gun, 761-0793

Japan

Kanagawa Cardiovascular and Respiratory Center

Kanagawa, Yokohama, 236-0051

Japan

Saiseikai Kumamoto Hospital

Kumamoto, Kumamoto, 861-4193

Japan

Tohoku University Hospital

Miyagi, Sendai, 980-8574

Japan

Nagasaki University Hospital

Nagasaki, Nagasaki, 852-8501

Japan

Kindai University Hospital

Osaka, Sakai, 590-0197

Japan

National Hospital Organization Kinki-Chuo Chest Medical Center

Osaka, Sakai, 591-8555

Japan

Osaka Medical and Pharmaceutical University Hospital

Osaka, Takatsuki, 569-8686

Japan

Saitama Red Cross Hospital

Saitama, Saitama, 330-8553

Japan

Shimane University Hospital

Shimane, Izumo, 693-8501

Japan

Hamamatsu University Hospital

Shizuoka, Hamamatsu, 431-3192

Japan

Jichi Medical University Hospital

Tochigi, Shimotsuke, 329-0498

Japan

Tokushima University Hospital

Tokushima, Tokushima, 770-8503

Japan

Juntendo University Hospital

Tokyo, Bunkyo-ku, 113-8431

Japan

Nippon Medical School Hospital

Tokyo, Bunkyo-ku, 113-8603

Japan

Toranomon Hospital

Tokyo, Minato-ku, 105-8470

Japan

Kyorin University Hospital

Tokyo, Mitaka, 181-8611

Japan

Toho University Omori Medical Center

Tokyo, Ota-ku, 143-8541

Japan

Tokyo Medical University Hospital

Tokyo, Shinjuku-ku, 160-0023

Japan

Keio University Hospital

Tokyo, Shinjuku-ku, 160-8582

Japan

National Center for Global Health and Medicine

Tokyo, Shinjuku-ku, 162-8655

Japan

Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510

Japan

Hospital Pulau Pinang-Pulau Pinang-21953

George Town, 10990

Malaysia

Hospital Sultan Idris Shah Serdang

Kajang, 43000

Malaysia

Institut Perubatan Respiratori

Kuala Lumpur, 53000

Malaysia

Sarawak General Hospital

Kuching, 93586

Malaysia

Centro de Investigacion Integral MEDIVEST S.C

Chihuahua City, 31203

Mexico

CREPID Aire y Salud Integral

Coyoacán, 04380

Mexico

Centro de Investigacion Farmacologica del Bajío, S.C.

León, 37160

Mexico

Soltmed Smo

Mexico City, 03650

Mexico

Centro Respiratorio de Mexico

Mexico City, 14050

Mexico

Centro de Prevención y Rehabilitación de Enfermedades Pulmon

Monterrey, 64460

Mexico

Oaxaca Site Management Organization, S.C.

Oaxaca City, 68000

Mexico

Zuyderland Medisch Centrum

HEERLENHeerlen, 6419

Netherlands

Leids Universitair Medisch Centrum (LUMC)

Leiden, 2333

Netherlands

St. Antonius Ziekenhuis

Nieuwegein, 3435 CM

Netherlands

Erasmus Medisch Centrum-ROTTERDAM-50697

Rotterdam, 3015

Netherlands

Aotearoa Clinical Trials

Papatoetoe, Auckland 2025

New Zealand

Waikato Hospital

Hamilton, 3204

New Zealand

Greenlane Clinical Centre

One Tree Hill, Auckland, 1051

New Zealand

Tauranga Hospital

Tauranga South, 3112

New Zealand

Haukeland Universitetssykehus

Bergen, N-5021

Norway

Akershus Universitetssykehus HF

Nordbyhagen, 1478

Norway

Oslo Universitetssykehus HF, Rikshospitalet

Oslo, 0372

Norway

Uniwersyteckie Centrum Kliniczne

Gdansk, 80-214

Poland

Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ.

Katowice, 40-635

Poland

Przychodnia Alergologiczno-Pulmonologiczna Alergopneuma Sp. z o.o.

Świdnik, 21 040

Poland

Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa

Warsaw, 01-138

Poland

University Clinical Center of the Medical University of Warsaw

Warsaw, 02097

Poland

ULS Braga

Braga, 4710-243

Portugal

CHUC - Centro Hospitalar e Universitario de Coimbra, EPE

Coimbra, 3004-561

Portugal

ULS de São José, E.P.E.

Lisbon, 1169-024

Portugal

USLM, EPE - Hospital Pedro Hispano

Matosinhos Municipality, 4454-509

Portugal

Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E

Vila Nova de Gaia, 4434-502

Portugal

King Abdullah International Medical Research Center

Riyadh, 11481

Saudi Arabia

University Clinical Center of Serbia

Belgrade, 11000

Serbia

Institute for Pulmonary Diseases of Vojvodina

Kamenitz, 21204

Serbia

University Clinical Center Nis

Niš, 18000

Serbia

Singapore General Hospital

Singapore, 169608

Singapore

Tan Tock Seng Hospital

Singapore, 308433

Singapore

Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases

Golnik, 4204

Slovenia

Enhancing Care Foundation NPC

Mount Edgecombe, 4301

South Africa

The Catholic University of Korea, Bucheon St.Mary's Hospital

Bucheon-si, 14647

South Korea

Seoul National University Bundang Hospital

Seongnam, 13620

South Korea

Kyung Hee University Hospital

Seoul, 02447

South Korea

Seoul National University Hospital

Seoul, 03080

South Korea

Severance Hospital

Seoul, 03722

South Korea

Soonchunhyang University Hospital Seoul

Seoul, 04401

South Korea

Asan Medical Center

Seoul, 05505

South Korea

Samsung Medical Center

Seoul, 135-710

South Korea

Hospital General Universitario de Alicante

Alicante, 03010

Spain

Hospital del Mar

Barcelona, 08003

Spain

Hospital Universitari Vall d'Hebron

Barcelona, 08035

Spain

Hospital Clínic de Barcelona

Barcelona, 08036

Spain

Hospital de Basurto

Bilbao, 48013

Spain

Hospital Universitario Virgen de la Arrixaca

El Palmar, 30120

Spain

Hospital de Galdakao

Galdakao, 48960

Spain

Hospital Universitario Virgen de las Nieves

Granada, 18014

Spain

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, 08907

Spain

Hospital Universitario De La Princesa

Madrid, 28006

Spain

Hospital General Universitario Gregorio Marañón

Madrid, 28007

Spain

Hospital Universitario Infanta Leonor

Madrid, 28031

Spain

Hospital Universitario Ramon Y Cajal

Madrid, 28034

Spain

Hospital Universitario 12 de Octubre

Madrid, 28041

Spain

Hospital Universitario Virgen de la Victoria

Málaga, 29010

Spain

Hospital Central de Asturias

Oviedo, 33011

Spain

Hospital Son Espases

Palma de Mallorca, 07120

Spain

Hospital Quirónsalud Madrid

Pozuelo de Alarcón, 28223

Spain

Hospital Universitario Marqués de Valdecilla

Santander, 39008

Spain

Hospital Clínico de Santiago

Santiago de Compostela, 15706

Spain

Hospital Virgen del Rocío

Seville, 41013

Spain

Hospital Nuestra Señora de Valme

Seville, 41014

Spain

Hospital General Universitario de Valencia

Valencia, 46014

Spain

Universitetssjukhuset, Linköping

Linköping, 581 85

Sweden

Akademiska sjukhuset

Uppsala, 75185

Sweden

Universitätsspital Basel

Basel, 4031

Switzerland

Changhua Christian Hospital

Changhua, 500

Taiwan

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 83301

Taiwan

Taichung Veterans General Hospital

Taichung, 407

Taiwan

NCKUH

Tainan, 704

Taiwan

National Taiwan University Hospital

Taipei, 100

Taiwan

Taipei Veterans General Hospital

Taipei, 11217

Taiwan

Siriraj Hospital

Bangkok Noi, 10700

Thailand

Srinagarind Hospital

Khon Kaen, 40002

Thailand

Maharat Nakhonchiangmai Hospital

Muang, 50200

Thailand

Ramathibodi Hospital

Ratchatewi, 10400

Thailand

Songklanagarind Hospital

Songkhla, 90110

Thailand

Gulhane Training and Research Hospital

Ankara, 06010

Turkey (Türkiye)

Ankara Universitesi Tip Fakultesi

Ankara, 06620

Turkey (Türkiye)

Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606

Antalya, 07070

Turkey (Türkiye)

Istanbul Universitesi Istanbul Tip Fakultesi

Çapa, 34390

Turkey (Türkiye)

Gazi Universitesi Tip Fakultesi

Yenimahalle/ANKARA, 06560

Turkey (Türkiye)

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZN

United Kingdom

Queen Elizabeth Hospital Birmingham

Birmingham, B15 2GW

United Kingdom

Southmead Hospital

Bristol, BS10 5NB

United Kingdom

Royal Infirmary of Edinburgh

Edinburgh, EH16 4SA

United Kingdom

Royal Devon and Exeter Hospital, Wonford

Exeter, EX2 5DW

United Kingdom

Royal Lancaster Infirmary

Lancaster, LA1 4RP

United Kingdom

St James's University Hospital

Leeds, LS9 7TF

United Kingdom

Guy's Hospital

London, SE1 9RT

United Kingdom

Royal Brompton Hospital

London, SW3 6NP

United Kingdom

Altnagelvin Area Hospital

Londonderry, BT47 6SB

United Kingdom

Wythenshawe Hospital

Manchester, M23 9QZ

United Kingdom

Churchill Hospital

Oxford, OX3 7LE

United Kingdom

Southampton General Hospital

Southampton, SO16 6YD

United Kingdom