Personalized Transcranial Direct Current Stimulation in Stroke Recovery
Start Date
12/18/2024
Completion Date
9/14/2027
Summary
The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement through increased connectivity as measured by a biomarker of plasticity.
Detailed Description
This is a randomized, sham controlled double masked parallel group study with optional crossover of chronic (\>3mo from stroke onset) ischemic or hemorrhagic stroke patients to test the effect of ptDCS on a cerebral connectivity biomarker of plasticity during stimulation and after 10 treatment of up to 2 mA ptDCS. PtDCS will be performed during the first 20 minutes of occupational therapy targeting the weaker arm compared to sham. Patients will have the option to cross over after the completion of 1-month follow-up and will complete the same procedures with real tDCS if they were in the sham group.
Eligibility Criteria
Age Range: 18 years to 80 years
Interventions
Transcranial direct current stimulation (tDCS) with OT
Sham tDCS with OT
Conditions
Locations
Houston Methodist Hospital
Houston, Texas 77030
United States