A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
Start Date
7/23/2024
Completion Date
5/30/2028
Summary
This is a first-in-human (FIH) clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of BGB-B2033 administered as monotherapy and in combination with tislelizumab, with or without bevacizumab. The study will enroll participants with locally advanced or metastatic hepatocellular carcinoma (HCC), alpha-fetoprotein (AFP)-producing gastric cancer (GC), extragonadal yolk sac tumors/non-dysgerminomas, or glypican-3 (GPC3)-positive squamous non-small cell lung cancer (NSCLC).
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BGB-B2033
Tislelizumab
Bevacizumab
Conditions
Locations
City of Hope Phoenix Cancer Center
Goodyear, Arizona 85338
United States
City of Hope National Medical Center
Duarte, California 91010-3012
United States
City of Hope Chicago Cancer Center
Zion, Illinois 60099
United States
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York 10065-6800
United States
Upmc Hillman Cancer Center(Univ of Pittsburgh)
Pittsburgh, Pennsylvania 15232-1309
United States
Scri Oncology Partners
Nashville, Tennessee 37203-1503
United States
The University of Texas Md Anderson Cancer Center
Houston, Texas 77030-4009
United States
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre, 90110-270
Brazil
Hospital Da Bahia
Salvador, 41810-011
Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
São José do Rio Preto, 15090-000
Brazil
Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira
São Paulo, 01246-000
Brazil
Anhui Provincial Hospital
Hefei, Anhui 230000
China
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality 400030
China
Mengchao Hepatobiliary Hospital of Fujian Medical University
Fuzhou, Fujian 350028
China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong 510000
China
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong 510515
China
Guangxi Medical University Cancer Hospital Wuxiang Branch
Nanning, Guangxi 530201
China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei 050011
China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang 150000
China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei 430022
China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei 430030
China
Hunan Cancer Hospital
Changsha, Hunan 410013
China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu 221000
China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330006
China
The Second Affiliated Hospital of Nanchang Universityhongjiaozhou Branch
Nanchang, Jiangxi 330038
China
Sichuan Cancer Hospital and Institute
Chengdu, Sichuan 610041
China
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang 310003
China
Lishui Central Hospital
Lishui, Zhejiang 323000
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang 325000
China
Hopital Beaujon
Clichy, 92110
France
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, 44000
France
Institut Gustave Roussy
Villejuif, 94800
France
Irccs Istituto Nazionale Tumori Fondazione Pascale
Naples, 80131
Italy
Iov Istituto Oncologico Veneto Irccs
Padova, 35128
Italy
Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168
Italy
Irccs Humanitas Research Hospital
Rozzano, 20089
Italy
Kindai University Hospital
Sakai, Osaka 590-0197
Japan
Tokyo Metropolitan Komagome Hospital
Bunkyoku, Tokyo 113-8677
Japan
Cancer Institute Hospital of Jfcr
Kotoku, Tokyo 135-8550
Japan
Auckland City Hospital
Auckland, 1023
New Zealand
Hospital Oncologico
Rio Piedras, 00935
Puerto Rico
Chungbuk National University Hospital
Cheongju-si, Chungcheongbukdo 28644
South Korea
Cha Bundang Medical Center, Cha University
BundangGu SeongnamSi, Gyeonggi-do 13496
South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi 06351
South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi 03722
South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi 03080
South Korea
Asan Medical Center
SongpaGu, Seoul Teugbyeolsi 05505
South Korea