A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
Start Date
11/18/2024
Completion Date
5/2/2030
Summary
This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned. The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemiplimab plus chemotherapy without the additional drug. The study is also looking at several other research questions, including: * What are the side effects associated with the investigational treatments in comparison to the control treatment? * Do the investigational treatments or the control treatment have an effect on the type of surgery that is performed? * How much of the study drug(s) are in the blood at a given time? * Does the body make antibodies against the study drug(s) (which could make the drug(s) less effective or could lead to side effects)?
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Cemiplimab
Platinum-based chemotherapy
REGN7075
Conditions
Locations
University of California Irvine
Orange, California 92868
United States
Orchard Healthcare Research Inc.
Skokie, Illinois 60077
United States
Karmanos Cancer Institute
Detroit, Michigan 48201
United States
Detroit Clinical Research Center
Farmington Hills, Michigan 48334
United States
Morristown Medical Center
Morristown, New Jersey 07960
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08901
United States
Oncology Hematology Care Clinical Trials LLC
Cincinnati, Ohio 45245
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
University Of Nebraska Medical Center
Portland, Oregon 97213
United States
Lifespan Cancer Institute
Providence, Rhode Island 02903
United States
Prairie Lakes Healthcare System
Watertown, South Dakota 57201
United States
University of Tennessee Medical Center
Knoxville, Tennessee 37920
United States
Sarah Cannon Research Institute (SCRI) Oncology Partners
Nashville, Tennessee 37203
United States
Tennessee Oncology
Nashville, Tennessee 37203
United States
BRCC/Oncology & Hematology Associates of SW Virginia
Blacksburg, Virginia 24060
United States
Oncology Clinical Research Center
Cachoeiro de Itapemirim, Espírito Santo 29306014
Brazil
Instituto Mario Penna
Belo Horizonte, Minas Gerais 30380-472
Brazil
Instituto Sul Mineiro De Oncologia LTDA
Pouso Alegre, Minas Gerais 37554-238
Brazil
Instituto de Medicina Integral Professor Fernando Figueira
Recife, Pernambuco 50070-902
Brazil
Liga Norte Riograndense Contra o Cancer
Natal, Rio Grande do Norte 59060-195
Brazil
Hospital Mae de Deus Integrated Oncology Center
Porto Alegre, Rio Grande do Sul 90110-270
Brazil
Hospital Sao Lucas da PUCRS
Porto Alegre, Rio Grande do Sul 90610-000
Brazil
Ynova Pesquisa Clinica
Florianópolis, Santa Catarina 88020-210
Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
São José do Rio Preto, São Paulo 15090-000
Brazil
Unimed Sorocaba
Sorocaba, São Paulo 18065-100
Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903
Brazil
CHU Rennes
Rennes, Brittany Region 35033
France
Centre Hospitalier Intercommunal Toulon - CHITS
Toulon, Var 83055
France
Centre Hospitalier de la Cote Basque
Bayonne, 64100
France
Clinique Belharra
Bayonne, 64100
France
CHU Grenoble Alpes
Grenoble, 38330
France
Montpellier Academic Hospital
Montpellier, 34295
France
Institut Curie
Paris, Île-de-France Region 75005
France
Klinikum Kassel GmbH, Hauttumorzentrum
Kassel, Hesse 34125
Germany
University Medicine Gottingen
Göttingen, Lower Saxony 37083
Germany
University of Leipzig
Leipzig, Saxony 04103
Germany
University Hospital RWTH Aachen
Aachen, 52074
Germany
Catalan Instituye of Oncology Badalona
Badalona, Barcelona 08916
Spain
Hospital Valdecilla
Santander, Cantabria 39008
Spain
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, Las Palmas 35016
Spain
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
MD Anderson Cancer Center
Madrid, 28033
Spain
Hospital Universitario Clinico San Carlos
Madrid, 28040
Spain
Hospital Universitario La Paz
Madrid, 28046
Spain
Hospital Universitario HM Sanchinarro
Madrid, 28050
Spain
Hospital Virgen del Rocio
Seville, 41013
Spain
Hospital Clinico Universitario Valencia
Valencia, 46010
Spain
Consorci Hospital General Universitario de Valencia
Valencia, 46014
Spain
Hospital Clinico Lozano Blesa
Zaragoza, 50009
Spain
Florya Medical Park Hospital
Istanbul, 34295
Turkey (Türkiye)