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NCT06476808PHASE1Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Bristol-Myers Squibb

Start Date

9/6/2024

Completion Date

12/19/2028

Summary

The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria * Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. * Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained. * Participants must have an unresectable/metastatic carcinoma. Exclusion Criteria * Participants must not have Leptomeningeal metastases. * Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment. * Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment. * Other protocol-defined Inclusion/Exclusion criteria apply.

Interventions

DRUG

BMS-986463

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Conditions

High-grade Serous Ovarian Carcinoma (HGSOC)Uterine Serous Carcinoma (USC)Non-small Cell Lung Cancer (NSCLC)

Locations

USC/Norris Comprehensive Cancer Center

Los Angeles, California 90033

United States

Valkyrie Clinical Trials

Los Angeles, California 90067

United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey 07601

United States

Local Institution - 0045

Columbus, Ohio 43210

United States

Local Institution - 0046

Dallas, Texas 75390

United States

Local Institution - 0049

Houston, Texas 77054

United States

BC Cancer Vancouver

Vancouver, British Columbia V5Z 4E6

Canada

Princess Margaret Cancer Centre

Toronto, Ontario M5G 2M9

Canada

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec H2X 3E4

Canada

Jewish General Hospital

Montreal, Quebec H3T 1E2

Canada

Local Institution - 0036

Bordeaux, Aquitaine 33076

France

Local Institution - 0031

Villejuif, Val-de-Marne 94800

France

Local Institution - 0035

Lyon, 69373

France

Local Institution - 0033

Milan, 20141

Italy

Local Institution - 0032

Milan, 20159

Italy

Local Institution - 0042

Barcelona, Barcelona [Barcelona] 08035

Spain

Local Institution - 0041

Avda.Pio XII 36,, 31008

Spain