Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)

Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits. 3. Male or Female age \>18 years old. 4. In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery. 5. Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5) 6. Intact coronal restorations with no evidence of leakage or caries under the restoration. Exclusion Criteria: 1. Minors. 2. Suspected root fractures. 3. ASA classification 3 or greater. 4. Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5). 5. Patients with history of Oral or IV Bisphosphonate use. 6. Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.