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NCT06605378Recruiting

Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

Ensoma

Start Date

11/18/2024

Completion Date

6/1/2026

Summary

This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.

Detailed Description

In this observational study, blood samples will be collected from adult and pediatric patients with CGD. The level of circulating adenovirus antibodies and inflammatory cytokines will be measured to characterize the prevalence of these markers in this population.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1). * The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent. * The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF). Exclusion Criteria: * The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy. * The participant is unable to comply with the sample collection procedure based on investigator judgment.

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Conditions

Chronic Granulomatous Disease (CGD)

Locations

Home-based telemedicine

Montgomery, Alabama 36104

United States

Home-based telemedicine

Phoenix, Arizona 85001

United States

Home-based telemedicine

Little Rock, Arkansas 72201

United States

Home-based telemedicine

Sacramento, California 95814

United States

University of California, San Francisco

San Francisco, California 94158

United States

Home-based telemedicine

Denver, Colorado 80202

United States

Home-based telemedicine

Hartford, Connecticut 06103

United States

Home-based telemedicine

Dover, Delaware 19901

United States

Home-based telemedicine

Washington D.C., District of Columbia 20001

United States

Home-based telemedicine

Tallahassee, Florida 32301

United States

Home-based telemedicine

Atlanta, Georgia 30303

United States

Home-based telemedicine

Boise, Idaho 83702

United States

Home-based telemedicine

Springfield, Illinois 62701

United States

Home-based telemedicine

Indianapolis, Indiana 46225

United States

Home-based telemedicine

Des Moines, Iowa 50309

United States

Home-based telemedicine

Topeka, Kansas 66603

United States

Home-based telemedicine

Frankfort, Kentucky 40601

United States

Home-based telemedicine

Baton Rouge, Louisiana 70802

United States

Home-based telemedicine

Augusta, Maine 04330

United States

Home-based telemedicine

Annapolis, Maryland 21401

United States

Home-based telemedicine

Boston, Massachusetts 02210

United States

Home-based telemedicine

Lansing, Michigan 48933

United States

Home-based telemedicine

Saint Paul, Minnesota 55102

United States

Home-based telemedicine

Jackson, Mississippi 39205

United States

Home-based telemedicine

Jefferson City, Missouri 65101

United States

Home-based telemedicine

Helena, Montana 59623

United States

Home-based telemedicine

Lincoln, Nebraska 68502

United States

Home-based telemedicine

Carson City, Nevada 89701

United States

Home-based telemedicine

Concord, New Hampshire 03301

United States

Home-based telemedicine

Trenton, New Jersey 08608

United States

Home-based telemedicine

Santa Fe, New Mexico 87501

United States

Home-based telemedicine

Albany, New York 12207

United States

Science 37, Inc

Morrisville, North Carolina 27560

United States

Home-based telemedicine

Bismarck, North Dakota 58501

United States

Home-based telemedicine

Columbus, Ohio 43215

United States

Home-based telemedicine

Oklahoma City, Oklahoma 73102

United States

Home-based telemedicine

Salem, Oregon 97301

United States

Home-based telemedicine

Harrisburg, Pennsylvania 17101

United States

Home-based telemedicine

Providence, Rhode Island 02903

United States

Home-based telemedicine

Columbia, South Carolina 29217

United States

Home-based telemedicine

Pierre, South Dakota 57501

United States

Home-based telemedicine

Nashville, Tennessee 37219

United States

Home-based telemedicine

Austin, Texas 78701

United States

Home-based telemedicine

Salt Lake City, Utah 84111

United States

Home-based telemedicine

Montpelier, Vermont 05602

United States

Home-based telemedicine

Richmond, Virginia 23219

United States

Home-based telemedicine

Olympia, Washington 98507

United States

Home-based telemedicine

Charleston, West Virginia 25301

United States

Home-based telemedicine

Madison, Wisconsin 53703

United States

Home-based telemedicine

Cheyenne, Wyoming 82001

United States

Great Ormond Street Hospital for Children

London, WC1N 3JH

United Kingdom

Royal Free London NHS Foundation Trust

London,

United Kingdom