A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
Start Date
3/12/2025
Completion Date
6/22/2032
Summary
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BMS-986393
Cyclophosphamide
Fludarabine
Daratumumab
Pomalidomide
Dexamethasone
Carfilzomib
Conditions
Locations
University of Alabama at Birmingham
Birmingham, Alabama 35205
United States
UCLA Hematology/Oncology - Santa Monica
Los Angeles, California 90404
United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Orange, California 92868
United States
Local Institution - 0223
Washington D.C., District of Columbia 20007
United States
Baptist MD Anderson Cancer Center
Jacksonville, Florida 32207
United States
University of Miami Hospital and Clinics, Sylvester Cancer Center
Miami, Florida 33136
United States
Local Institution - 0228
Orlando, Florida 32804
United States
Winship Cancer Institute, Emory University
Atlanta, Georgia 30322
United States
Louisiana State University Health Sciences Shreveport
Shreveport, Louisiana 71103
United States
Boston Medical Center
Boston, Massachusetts 02118
United States
Local Institution - 0219
Minneapolis, Minnesota 55455
United States
Weill Cornell Medical College
New York, New York 10065
United States
Local Institution - 0221
Stony Brook, New York 11794
United States
Levine Cancer Institute
Charlotte, North Carolina 28204
United States
Levine Cancer Institute
Charlotte, North Carolina 28204
United States
Cleveland Clinic
Cleveland, Ohio 44195
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
Local Institution - 0232
Pittsburgh, Pennsylvania 15224
United States
Local Institution - 0227
Charleston, South Carolina 29425
United States
University of Texas MD Anderson Cancer Center
Houston, Texas 77030
United States
Huntsman Cancer Institute
Salt Lake City, Utah 84112
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Hospital Italiano de Buenos Aires
ABB, Buenos Aires F.D. C1199ABB
Argentina
Local Institution - 0214
ABB, Buenos Aires F.D. C1199ABB
Argentina
Hospital Aleman
Buenos Aires, Buenos Aires F.D. C1118AAT
Argentina
Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
Australia
Liverpool Hospital
Liverpool, New South Wales 2170
Australia
Princess Alexandra Hospital
Brisbane, Queensland 4102
Australia
Royal Adelaide Hospital
Adelaide, South Australia 5000
Australia
Monash Health
Clayton, Victoria 3168
Australia
Peter MacCallum Cancer Centre
Melbourne, Victoria 3000
Australia
The Alfred Hospital
Melbourne, Victoria 3004
Australia
Fiona Stanley Hospital
Murdoch, Western Australia 6150
Australia
Ordensklinikum Linz GmbH Elisabethinen
Linz, Upper Austria 4020
Austria
Hanusch-Krankenhaus
Vienna, 1140
Austria
Antwerp University Hospital
Edegem, Antwerpen 2650
Belgium
Cliniques universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région de 1200
Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
Yvoir, Namur 5530
Belgium
UZ Gent
Ghent, Oost-Vlaanderen 9000
Belgium
Local Institution - 0012
Nova Lima, Minas Gerais 34000-000
Brazil
A. C. Camargo Cancer Center
São Paulo, São Paulo 01509-010
Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 01401-002
Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652-900
Brazil
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta T2N 5G2
Canada
Vancouver General Hospital
Vancouver, British Columbia V5Z 1M9
Canada
QEII Health Sciences Centre - Victoria General Site
Halifax, Nova Scotia B3H 2Y9
Canada
Local Institution - 0192
Hamilton, Ontario L8V5C2
Canada
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec H1T 2M4
Canada
Fakultní nemocnice Brno Bohunice
Brno, Brno-město 625 00
Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, Hradec Králové 500 05
Czechia
Fakultni nemocnice Ostrava
Ostrava, Moravian-Silesian Region 708 52
Czechia
Vseobecna fakultni nemocnice v Praze
Prague, 12808
Czechia
Rigshospitalet
Copenhagen, Capital Region 2100
Denmark
Aarhus Universitetshospital, Skejby
Aarhus, Central Jutland 8200
Denmark
Roskilde Sygehus
Roskilde, Region Sjælland 4000
Denmark
Odense Universitetshospital
Odense, Region Syddanmark 5000
Denmark
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
Helsinki, Uusimaa 00029
Finland
Oulun yliopistollinen sairaala
Oulu, 90220
Finland
Turku University Hospital
Turku, 20251
Finland
Hopital Claude Huriez - CHU de Lille
Lille, Nord 59000
France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
Nantes, Pays de la Loire Region 44000
France
Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône 69310
France
Henri Mondor Hospital
Créteil, Val-de-Marne 94010
France
Hôpital Saint-Louis
Paris, 75010
France
TUM Klinikum
Munich, Bavaria 81675
Germany
Medizinische Hochschule Hannover
Hanover, Lower Saxony 30625
Germany
Klinikum Chemnitz - Flemmingstraße
Chemnitz, Saxony 09116
Germany
Universitätsklinikum Leipzig
Leipzig, Saxony 04103
Germany
Universitaetsklinikum Magdeburg
Magdeburg, Saxony-Anhalt 39120
Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, Schleswig-Holstein 24105
Germany
Charité Campus Virchow-Klinikum
Berlin, 13353
Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20246
Germany
Universitaetsklinikum Heidelberg
Heidelberg, D-69120
Germany
Klinikum Nuernberg Nord
Nuremberg, 90419
Germany
Universitaetsklinikum Wuerzburg
Würzburg, 97080
Germany
University Hospital of Patras
Pátrai, Achaḯa 26504
Greece
Evangelismos General Hospital of Athens
Athens, Attikí 106 76
Greece
Attikon General University Hospital
Chaïdári, Attikí 12462
Greece
Debreceni Egyetem Klinikai Kozpont
Debrecen, Hajdú-Bihar 4032
Hungary
Local Institution - 0125
Budapest, 1097
Hungary
Sheba Medical Center
Ramat Gan, Central District 5262100
Israel
Hadassah Medical Center
Jerusalem, Jerusalem 9112001
Israel
Sourasky Medical Center
Tel Aviv, Tell Abīb 6423906
Israel
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy 20133
Italy
Istituto Clinico Humanitas
Rozzano, Milano 20089
Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
Turin, Piedmont 10126
Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Italy
IRCCS AOM Azienda Ospedaliera Metropolitana
Genova, 16132
Italy
P.O. "S. Maria della Misericordia" Azienda Sanitaria Universitaria Friuli Centrale
Udine, 33100
Italy
Nagoya City University Hospital
Nagoya, Aichi-ken 467-8602
Japan
National Cancer Center Hospital East
Kashiwa, Chiba 277-8577
Japan
Hyogo Medical University Hospital
Nishinomiya, Hyōgo 663-8501
Japan
Kanazawa University Hospital
Kanazawa, Ishikawa-ken 920-8641
Japan
Japanese Red Cross Medical Center
Shibuya-ku, Tokyo 150-8935
Japan
Kyushu University Hospital
Fukuoka, 812-8582
Japan
Kumamoto University Hospital
Kumamoto, 860-8556
Japan
National Hospital Organization Okayama Medical Center
Okayama, 701-1192
Japan
Osaka Red Cross Hospital
Osaka, 543-8555
Japan
Yamagata University Hospital
Yamagata, 990-9585
Japan
Radboudumc
Nijmegen, Gelderland 6525 GA
Netherlands
Maastricht UMC+
Maastricht, Limburg 6229 HX
Netherlands
Amsterdam UMC, locatie VUmc
Amsterdam, North Holland 1081 HV
Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
Netherlands
Sykehusapoteket Ull
Oslo, 0450
Norway
Centrum Onkologii Ziemi Lubelskiej
Lublin, Lublin Voivodeship 20-090
Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship 80-214
Poland
Local Institution - 0084
Katowice, 40-519
Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
Lodz, Łódź Voivodeship 93-513
Poland
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
Porto, 4200-072
Portugal
Fundeni Clinical Institute
Bucharest, Bucharest 022328
Romania
Spitalul Universitar de Urgență București
Bucharest, 050098
Romania
Institutul Regional de Oncologie
Iași, 700483
Romania
Local Institution - 0178
Riyadh, 12713
Saudi Arabia
National University Hospital
Singapore, Central Singapore 119074
Singapore
Local Institution - 0181
Singapore, Central Singapore 169608
Singapore
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [Seoul] 03080
South Korea
Asan Medical Center
Seoul, Seoul-teukbyeolsi [Seoul] 05505
South Korea
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [Seoul] 06351
South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul-teukbyeolsi [Seoul] 06591
South Korea
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [La Coruña] 15706
Spain
Hospital Universitari Son Espases
Palma, Balears [Baleares] 07120
Spain
Institut Catalan d Oncologia (ICO) - Badalona
Badalona, Barcelona [Barcelona] 08916
Spain
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitario Virgen Nieves
Granada, 18012
Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca, 37007
Spain
Sahlgrenska Universitetssjukhuset
Gothenburg, Västra Götalands Län [se-14] 413 45
Sweden
Karolinska Universitetssjukhuset Huddinge
Huddinge, 141 86
Sweden
Skånes Universitetssjukhus Lund
Lund, 222 42
Sweden
Inselspital Bern
Bern, Canton of Bern 3010
Switzerland
Cantonal Hospital St.Gallen
Sankt Gallen, Canton of St. Gallen 9007
Switzerland
National Taiwan University Cancer Center (NTUCC)
Taipei City, Taipei 106
Taiwan
China Medical University Hospital
Taichung, 404332
Taiwan
National Taiwan University Hospital
Taipei, 10002
Taiwan
Taipei Veterans General Hospital
Taipei, 11217
Taiwan
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
Ankara, 06200
Turkey (Türkiye)
Addenbrooke's Hospital
Cambridge, Cambridgeshire CB2 2QQ
United Kingdom
University College London Hospital
London, London, City of NW1 2PG
United Kingdom
Churchill Hospital
Oxford, Oxfordshire OX3 7LE
United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX
United Kingdom
Freeman Hospital
Newcastle upon Tyne, NE7 7DN
United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, S10 2JF
United Kingdom